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AMPA receptors in the synapse turnover by monomer diffusion
https://oist.repo.nii.ac.jp/records/1258
https://oist.repo.nii.ac.jp/records/1258570ea297-3885-4a24-a90f-82a07bf31a70
名前 / ファイル | ライセンス | アクション |
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Morise-2019-AMPA receptors in the synapse turn (4.0 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | AMPA receptors in the synapse turnover by monomer diffusion | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Morise, Jyoji
× Morise, Jyoji× Suzuki, Kenichi G. N.× Kitagawa, Ayaka× Wakazono, Yoshihiko× Takamiya, Kogo× Tsunoyama, Taka A.× Nemoto, Yuri L.× Takematsu, Hiromu× Kusumi, Akihiro× Oka, Shogo |
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書誌情報 |
en : Nature Communications 巻 10, 号 1, p. 5245, 発行日 2019-11-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The number and subunit compositions of AMPA receptors (AMPARs), hetero- or homotetramers composed of four subunits GluA1-4, in the synapse is carefully tuned to sustain basic synaptic activity. This enables stimulation-induced synaptic plasticity, which is central to learning and memory. The AMPAR tetramers have been widely believed to be stable from their formation in the endoplasmic reticulum until their proteolytic decomposition. However, by observing GluA1 and GluA2 at the level of single molecules, we find that the homo- and heterotetramers are metastable, instantaneously falling apart into monomers, dimers, or trimers (in 100 and 200 ms, respectively), which readily form tetramers again. In the dendritic plasma membrane, GluA1 and GluA2 monomers and dimers are far more mobile than tetramers and enter and exit from the synaptic regions. We conclude that AMPAR turnover by lateral diffusion, essential for sustaining synaptic function, is largely done by monomers of AMPAR subunits, rather than preformed tetramers. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31748519 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-019-13229-8 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-019-13229-8 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |