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Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908
https://oist.repo.nii.ac.jp/records/1522
https://oist.repo.nii.ac.jp/records/15220a4050ac-7f56-4eb0-8ec4-7e56c87e9229
名前 / ファイル | ライセンス | アクション |
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Manuscript_revised_final_200524 (520.5 kB)
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41429_2019_265_MOESM1_ESM (932.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-05-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hashimoto, Takuya
× Hashimoto, Takuya× Kozone, Ikuko× Hashimoto, Junko× Ueoka, Reiko× Kagaya, Noritaka× Fujie, Manabu× Sato, Noriyuki× Ikeda, Haruo× Shin-ya, Kazuo |
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書誌情報 |
en : The Journal of Antibiotics 巻 73, 号 3, p. 171-174, 発行日 2019-12-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In the course of our studies on the heterologous expression of giant biosynthetic genes, we discovered a novel cryptic biosynthetic gene cluster in Streptomyces rochei IFO12908. During our efforts to express biosynthetic genes using the host SUKA strain derived from Streptomyces avermitilis, a novel polyene macrolactam compound designated as JBIR-156 was produced. We report herein the cloning and heterologous expression of the JBIR-156 biosynthetic gene cluster, and the isolation, structure determination, and cytotoxic activity of this novel compound. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-8820 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1881-1469 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31853031 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41429-019-0265-x | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s), under exclusive licence to the Japan Antibiotics Research Association | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/s41429-019-0265-x | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |