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An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway
https://oist.repo.nii.ac.jp/records/1543
https://oist.repo.nii.ac.jp/records/1543fab49436-3d58-42bd-aa44-89d086f33c0d
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S0893608017302034-main (14.7 MB)
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Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Aoki, Sho
× Aoki, Sho× Smith, Jared B× Li, Hao× Yan, Xunyi× Igarashi, Masakazu× Coulon, Patrice× Wickens, Jeffery R× Ruigrok, Tom JH× Jin, Xin |
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書誌情報 |
en : eLife 巻 8, p. e49995, 発行日 2019-09-06 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cortico-basal ganglia-thalamocortical loops are largely conceived as parallel circuits that process limbic, associative, and sensorimotor information separately. Whether and how these functionally distinct loops interact remains unclear. Combining genetic and viral approaches, we systemically mapped the limbic and motor cortico-basal ganglia-thalamocortical loops in rodents. Despite largely closed loops within each functional domain, we discovered a unidirectional influence of the limbic over the motor loop via ventral striatum-substantia nigra (SNr)-motor thalamus circuitry. Slice electrophysiology verifies that the projection from ventral striatum functionally inhibits nigro-thalamic SNr neurons. In vivo optogenetic stimulation of ventral or dorsolateral striatum to SNr pathway modulates activity in medial prefrontal cortex (mPFC) and motor cortex (M1), respectively. However, whereas the dorsolateral striatum-SNr pathway exerts little impact on mPFC, activation of the ventral striatum-SNr pathway effectively alters M1 activity. These results demonstrate an open cortico-basal ganglia loop whereby limbic information could modulate motor output through ventral striatum control of M1. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31490123 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.49995 | |||||
権利 | ||||||
権利情報 | © 2019 Aoki et al. | |||||
情報源 | ||||||
関連名称 | http://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/49995 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |