2021/07/27 OISTIR uses the JAIRO Cloud for the institutional repository platform. This system was scheduled for a significant update, but it has been postponed. We will announce that the new schedule will be confirmed. Currently, OISTIR is available without restrictions. 2019/07/09 Accepted Manuscripts Submission has been created. Please access it from HERE (OIST employee only)
Sulfones and sulfonamides with an α-CH bond can be easily alkylated by aliphatic alcohols to add the carbon skeleton of the alcohol via a one-step, Ru(II)-catalyzed redox neutral reaction. The reaction requires a substoichiometric amount of base and produces only water as a byproduct. Several pharmaceutically relevant functional groups such as piperidine, morpholine, etc. are well-tolerated under the reaction conditions to give higher value-added products in one step from widely available substrates. The reaction proceeds through a sulfone carbanion addition to an in-situ-generated aldehyde formed via catalytic dehydrogenation and subsequent catalyst-mediated replacement of the secondary alcohol by hydrogen.
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Catalytic Sulfone Upgrading Reaction with Alcohols via Ru(II)
Just Accepted online version-1
(286.68KB)
