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Graphene based field-effect transistor biosensors functionalized using gas-phase synthesized gold nanoparticles
https://oist.repo.nii.ac.jp/records/1633
https://oist.repo.nii.ac.jp/records/1633907bbf41-a27f-42cb-afef-ba714cd58c87
名前 / ファイル | ライセンス | アクション |
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Danielson-2020-Graphene based field-effect tra (1.2 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Graphene based field-effect transistor biosensors functionalized using gas-phase synthesized gold nanoparticles | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Danielson, Eric
× Danielson, Eric× Sontakke, Vyankat A.× Porkovich, Alexander J.× Wang, Zhenwei× Kumar, Pawan× Ziadi, Zakaria× Yokobayashi, Yohei× Sowwan, Mukhles |
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書誌情報 |
en : Sensors and Actuators B: Chemical 巻 320, p. 128432, 発行日 2020-06-09 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Research has focused on graphene for developing the next generation of label-free biosensors, capable of highly sensitive and specific detection of DNA or other biomolecules. The binding of charged analytes to the one-atom thick layer of graphene can greatly affect its electronic properties. However, graphene is highly chemically inert, thus surface functionalization through chemical treatment is typically necessary to immobilize receptors of the target biological analyte on the graphene. In this work, we use gas-phase synthesized gold nanoparticles (Au NPs) to functionalize and bind a DNA aptamer to the graphene surface. The graphene is employed in a liquid gated field-effect transistor (FET) configuration to detect the hybridization of the complementary DNA strand, as well as the protein streptavidin, at attomolar level (aM, 10−18 mol L−1). The sensor shows a high dynamic detecting range from aM to picomolar (pM) levels (10-18 to 10-12 mol L−1), can discriminate between a complementary strand anda single nucleotide polymorphism (SNP)containing strand, and achieves adetection limit as low as 15aM. The high detection limit suggests that decorating biosensors with Au NPs synthesized from magnetron sputtering inert gas condensing technique is a promising method for biosensor functionalization, particularly for larger-area sensors that employ two-dimensional materials such as graphene. | |||||
出版者 | ||||||
出版者 | Elsevier B.V | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0925-4005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.snb.2020.128432 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s) | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0925400520307772?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |