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Promoting Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly
https://oist.repo.nii.ac.jp/records/1746
https://oist.repo.nii.ac.jp/records/17462466d555-b92d-45a1-85c4-df55114dd9d8
名前 / ファイル | ライセンス | アクション |
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ami-2020 (5.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Promoting Dual-Targeting Anticancer Effect by Regulating the Dynamic Intracellular Self-Assembly | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | dual-targeting | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | instructed self-assembly | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | anticancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chlorambucil | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ER stress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zhang, Shijin
× Zhang, Shijin× Zhang, Ye |
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書誌情報 |
en : ACS Applied Materials & Interfaces 巻 12, 号 37, p. 41105-41112, 発行日 2020-08-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Despite the promise of nanomedicine in the fight against complex diseases, the enthusiasm for its pharmaceutical development is backed by the elevated costs associated with the R&D process. Therefore, as a compromise solution, nanotechnology was mainly applied as a drug delivery system to improve bioavailability and controllability of pharmaceutical drugs. Attempting to break the restrictions without elevating potential costs, we multiply the functions of excipients in the nanodelivery system by endowing subcellular-targeting ability. To prove the concept, fluorescent endoplasmic reticulum-targeted short peptides were covalently connected to chemotherapy medication chlorambucil achieving enhanced drug-loading efficiency. Via visualized intracellular dynamic enzyme-catalyzed hydrolysis, the ER-targeting excipient and nucleus-targeting chlorambucil are released simultaneously, achieving a synergistic anticancer effect and elucidating the influence of intracellular self-assembly transition on enzymatic reactions. | |||||
出版者 | ||||||
出版者 | American Chemical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1944-8244 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1944-8252 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32819089 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1021/acsami.0c12271 | |||||
権利 | ||||||
権利情報 | © 2020 American Chemical Society | |||||
権利 | ||||||
権利情報 | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsami.0c12271 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://pubs.acs.org/doi/10.1021/acsami.0c12271 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |