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Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes
https://oist.repo.nii.ac.jp/records/1750
https://oist.repo.nii.ac.jp/records/175034c9d4e8-9261-4474-bfb1-969db2297f30
名前 / ファイル | ライセンス | アクション |
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Mutation_rate_depository (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | endosymbionts | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genetic drift | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genome evolution | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | genome size | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | gene loss | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Muller’s Ratchet | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mutation rate | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DNA repair | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | phylogenetic tree | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Bourguignon, Thomas
× Bourguignon, Thomas× Kinjo, Yukihiro× Villa-Martín, Paula× Coleman, Nicholas V.× Tang, Qian× Arab, Daej A.× Wang, Zongqing× Tokuda, Gaku× Hongoh, Yuichi× Ohkuma, Moriya× Ho, Simon Y.W.× Pigolotti, Simone× Lo, Nathan |
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書誌情報 |
en : Current Biology 巻 30, 号 19, p. 3848-3855.e4, 発行日 2020-08-06 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The evolutionary processes that drive variation in genome size across the tree of life remain unresolved. Effective population size (Ne) is thought to play an important role in shaping genome size [1, 2, 3]—a key example being the reduced genomes of insect endosymbionts, which undergo population bottlenecks during transmission [4]. However, the existence of reduced genomes in marine and terrestrial prokaryote species with large Ne indicate that genome reduction is influenced by multiple processes [3]. One candidate process is enhanced mutation rate, which can increase adaptive capacity but can also promote gene loss. To investigate evolutionary forces associated with prokaryotic genome reduction, we performed molecular evolutionary and phylogenomic analyses of nine lineages from five bacterial and archaeal phyla. We found that gene-loss rate strongly correlated with synonymous substitution rate (a proxy for mutation rate) in seven of the nine lineages. However, gene-loss rate showed weak or no correlation with the ratio of nonsynonymous/synonymous substitution rate (dN/dS). These results indicate that genome reduction is largely associated with increased mutation rate, while the association between gene loss and changes in Ne is less well defined. Lineages with relatively high dS and dN, as well as smaller genomes, lacked multiple DNA repair genes, providing a proximate cause for increased mutation rates. Our findings suggest that similar mechanisms drive genome reduction in both intracellular and free-living prokaryotes, with implications for developing a comprehensive theory of prokaryote genome size evolution. | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0960-9822 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1879-0445 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32763167 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.cub.2020.07.034 | |||||
権利 | ||||||
権利情報 | This article/chapter was published Current Biology, Volume 30, Issue 19, Thomas Bourguignon, Yukihiro Kinjo, Paula Villa-Martín, Nicholas V. Coleman, Qian Tang, Daej A. Arab, Zongqing Wang, Gaku Tokuda, Yuichi Hongoh, Moriya Ohkuma, Simon Y.W. Ho, Simone Pigolotti, Nathan Lo, Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes, Pages 3848-3855.e4, © 2020 Elsevier Inc. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0960982220310265 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |