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Metabolomics of human fasting: new insights about old questions
https://oist.repo.nii.ac.jp/records/1760
https://oist.repo.nii.ac.jp/records/176088742f8d-c561-419e-a35b-5735467c10f9
名前 / ファイル | ライセンス | アクション |
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rsob.200176 (583.5 kB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Metabolomics of human fasting: new insights about old questions | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ageing | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | antioxidant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | blood metabolites | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | metabolomics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | prolonged fasting | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | signalling metabolites. | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kondoh, Hiroshi
× Kondoh, Hiroshi× Teruya, Takayuki× Yanagida, Mitsuhiro |
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書誌情報 |
en : Open Biology 巻 10, 号 9, p. 200176, 発行日 2020-09-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Since ancient days, human fasting has been performed for religious or political reasons. More recently, fasting has been employed as an effective therapy for weight reduction by obese people, and numerous studies have investigated the physiology of fasting by obese subjects. Well-established fasting markers (butyrates, BCAAs and carnitines) were considered essential energy substitutes after glycogen storage depletion. However, a recently developed metabolomic approach has unravelled previously unappreciated aspects of fasting. Surprisingly, one-third (44) of 120 metabolites investigated increase during 58 h of fasting, including antioxidative metabolites (carnosine, ophthalmic acid, ergothioneine and urates) and metabolites of entire pathways, such as the pentose phosphate pathway. Signalling metabolites (3-hydroxybutyrate and 2-oxoglutarate) and purines/pyrimidines may also serve as transcriptional modulators. Thus, prolonged fasting activates both global catabolism and anabolism, reprogramming metabolic homeostasis. | |||||
出版者 | ||||||
出版者 | The Royal Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2046-2441 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32931723 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1098/rsob.200176 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://royalsocietypublishing.org/doi/10.1098/rsob.200176 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |