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Receptor Guanylyl Cyclases in Sensory Processing
https://oist.repo.nii.ac.jp/records/214
https://oist.repo.nii.ac.jp/records/21487c74665-bba1-49ff-9914-fd0f0b055526
名前 / ファイル | ライセンス | アクション |
---|---|---|
fendo-07-00173 (528.3 kB)
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Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-15 | |||||
タイトル | ||||||
タイトル | Receptor Guanylyl Cyclases in Sensory Processing | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Receptor Guanylyl Cyclases in Sensory Processing | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Maruyama, Ichiro N.
× Maruyama, Ichiro N. |
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書誌情報 |
en : Frontiers in Endocrinology 巻 7, p. 173, 発行日 2017-01-11 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Invertebrate models have generated many new insights into transmembrane signaling by cell-surface receptors. This review focuses on receptor guanylyl cyclases (rGCs) and describes recent advances in understanding their roles in sensory processing in the nematode, Caenorhabditis elegans. A complete analysis of the C. elegans genome elucidated 27 rGCs, an unusually large number compared with mammalian genomes, which encode 7 rGCs. Most C. elegans rGCs are expressed in sensory neurons and play roles in sensory processing, including gustation, thermosensation, olfaction, and phototransduction, among others. Recent studies have found that by producing a second messenger, guanosine 3', 5'-cyclic monophosphate, some rGCs act as direct sensor molecules for ions and temperatures, while others relay signals from G protein-coupled receptors. Interestingly, genetic and biochemical analyses of rGCs provide the first example of an obligate heterodimeric rGC. Based on recent structural studies of rGCs in mammals and other organisms, molecular mechanisms underlying activation of rGCs are also discussed in this review. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-2392 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28123378 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fendo.2016.00173 | |||||
権利 | ||||||
権利情報 | © 2017 Maruyama. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fendo.2016.00173/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |