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Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex
https://oist.repo.nii.ac.jp/records/2253
https://oist.repo.nii.ac.jp/records/22530e146f66-70b8-4d40-9805-ec072a479b83
名前 / ファイル | ライセンス | アクション |
---|---|---|
Akiyama-fimmu-12-715675 (1) (1.2 MB)
|
CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-09-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mRNA decay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CCR4-NOT complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lymphocyte development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VDJ recombination | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Akiyama, Taishin
× Akiyama, Taishin× Yamamoto, Tadashi |
|||||
書誌情報 |
en : Frontiers in Immunology 巻 12, p. 715675, 発行日 2021-07-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism controlling mRNA abundance. The carbon catabolite repression 4 (CCR4)-negative on TATA-less (NOT) complex controls mRNA longevity by catalyzing mRNA deadenylation, which is the rate-limiting step in the mRNA decay pathway. mRNA decay, regulated by the CCR4-NOT complex, is required for differentiation of pro-B to pre-B cells and V(D)J recombination in pro-B cells. In this process, it is likely that the RNA-binding proteins, ZFP36 ring finger protein like 1 and 2, recruit the CCR4-NOT complex to specific target mRNAs, thereby inducing cell quiescence of pro-B cells. A recent study showed that the CCR4-NOT complex participates in positive selection of thymocytes. Mechanistically, the CCR4-NOT deadenylase complex inhibits abnormal apoptosis by reducing the expression level of mRNAs encoding pro-apoptotic proteins, which are otherwise up-regulated during positive selection. We discuss mechanisms regulating CCR4-NOT complex-dependent mRNA decay in lymphocyte development and selection. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-3224 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34349771 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fimmu.2021.715675 | |||||
権利 | ||||||
権利情報 | © 2021 Akiyama and Yamamoto. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fimmu.2021.715675/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |