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Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration
https://oist.repo.nii.ac.jp/records/2595
https://oist.repo.nii.ac.jp/records/25950099f9a5-4ace-4a6b-a79d-24abcfabe5a1
名前 / ファイル | ライセンス | アクション |
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fevo-10-769433 (2.9 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-03-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hemichordates | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | regeneration | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | stem-cell reprogramming genes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pou3 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SoxB1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Msxlx | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Klf1/2/4 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Humphreys, Tom
× Humphreys, Tom× Weiser, Keith× Arimoto, Asuka× Sasaki, Akane× Uenishi, Gene× Fujimoto, Brent× Kawashima, Takeshi× Taparra, Kekoa× Molnar, Janos× Satoh, Noriyuki× Marikawa, Yusuke× Tagawa, Kuni |
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書誌情報 |
en : Frontiers in Ecology and Evolution 巻 10, p. 769433, 発行日 2022-02-15 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hemichordate enteropneust worms regenerate extensively in a manner that resembles the regeneration for which planaria and hydra are well known. Although hemichordates are often classified as an extant phylogenetic group that may hold ancestral deuterostome body plans at the base of the deuterostome evolutionary line leading to chordates, mammals, and humans, extensive regeneration is not known in any of these more advanced groups. Here we investigated whether hemichordates deploy functional homologs of canonical Yamanaka stem cell reprogramming factors, Oct4, Sox2, Nanog, and Klf4, as they regenerate. These reprogramming factors are not expressed during regeneration of limbs, fins, eyes or other structures that represent the best examples of regeneration in chordates. We first examined Ptychodera flava EST libraries and identified Pf-Pou3, Pf-SoxB1, Pf-Msxlx, and Pf-Klf1/2/4 as most closely related to the Yamanaka factors, respectively. In situ hybridization analyses revealed that all these homologs are expressed in a distinct manner during head regeneration. Furthermore, Pf-Pou3 partially rescued the loss of endogenous Oct4 in mouse embryonic stem cells in maintaining the pluripotency gene expression program. Based on these results, we propose that hemichordates may have co-opted these reprogramming factors for their extensive regeneration or that chordates may have lost the ability to mobilize these factors in response to damage. The robustness of these pluripotency gene circuits in the inner cell mass and in formation of induced pluripotent stem cells from mammalian somatic cells shows that these programs are intact in humans and other mammals and that these circuits may respond to as yet unknown gene regulatory signals, mobilizing full regeneration in hemichordates. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2296-701X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fevo.2022.769433 | |||||
権利 | ||||||
権利情報 | © 2022 Humphreys, Weiser, Arimoto, Sasaki, Uenishi, Fujimoto, Kawashima, Taparra, Molnar, Satoh, Marikawa and Tagawa. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fevo.2022.769433/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |