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JunB Is Critical for Survival of T Helper Cells
https://oist.repo.nii.ac.jp/records/2733
https://oist.repo.nii.ac.jp/records/27333249d370-f37e-4b49-add1-7c77446a4b72
名前 / ファイル | ライセンス | アクション |
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fimmu-13-901030_vor (7.0 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | JunB Is Critical for Survival of T Helper Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clonal expansion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | JunB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T helper cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AP-1 – activator protein 1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hsieh, Tsunghan
× Hsieh, Tsunghan× Sasaki, Daiki× Taira, Naoyuki× Chien, Hsiaochiao× Sarkar, Shukla× Seto, Yu× Miyagi, Mio× Ishikawa, Hiroki |
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書誌情報 |
en : Frontiers in Immunology 巻 13, p. 901030, 発行日 2022-06-28 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clonal expansion and differentiation of various T helper subsets, such as Th1, Th2, and Th17 cells, depend on a complex of transcription factors, IRF4 and a BATF-containing AP-1 heterodimer. A major BATF heterodimeric partner, JunB, regulates Th17 differentiation, but the role of JunB in other T helper subsets is not well understood. Here we demonstrate that JunB is required for clonal expansion of Th1, Th2 and Th17 cells. In mice immunized with lipopolysaccharide (LPS), papain, or complete Freund’s adjuvant (CFA), which induce predominantly Th1, Th2 and Th17 cells, respectively, accumulation of antigen-primed, Junb-deficient CD4+ T cells is significantly impaired. TCR-stimulated Junb-deficient CD4+ T cells are more sensitive to apoptosis, although they showed largely normal proliferation and cellular metabolism. JunB directly inhibits expression of genes involved in apoptosis, including Bcl2l11 (encoding Bim), by promoting IRF4 DNA binding at the gene locus. Taken together, JunB serves a critical function in clonal expansion of diverse T helper cells by inhibiting their apoptosis. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-3224 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35837408 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fimmu.2022.901030 | |||||
権利 | ||||||
権利情報 | © 2022 Hsieh, Sasaki, Taira, Chien, Sarkar, Seto, Miyagi and Ishikawa. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fimmu.2022.901030/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |