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Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development
https://oist.repo.nii.ac.jp/records/2755
https://oist.repo.nii.ac.jp/records/275558e30e19-9332-410a-ab5f-279a18d8c22e
名前 / ファイル | ライセンス | アクション |
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sciadv.abn7702_am (3.0 MB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-08-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Mora-Bermúdez, Felipe
× Mora-Bermúdez, Felipe× Kanis, Philipp× Macak, Dominik× Peters, Jula× Naumann, Ronald× Xing, Lei× Sarov, Mihail× Winkler, Sylke× Oegema, Christina Eugster× Haffner, Christiane× Wimberger, Pauline× Riesenberg, Stephan× Maricic, Tomislav× Huttner, Wieland B.× Pääbo, Svante |
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書誌情報 |
en : Science Advances 巻 8, 号 30, p. eabn7702, 発行日 2022-07-29 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Since the ancestors of modern humans separated from those of Neanderthals, around 100 amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely unknown. Here, we examine all six such amino acid substitutions in three proteins known to have key roles in kinetochore function and chromosome segregation and to be highly expressed in the stem cells of the developing neocortex. When we introduce these modern human-specific substitutions in mice, three substitutions in two of these proteins, KIF18a and KNL1, cause metaphase prolongation and fewer chromosome segregation errors in apical progenitors of the developing neocortex. Conversely, the ancestral substitutions cause shorter metaphase length and more chromosome segregation errors in human brain organoids, similar to what we find in chimpanzee organoids. These results imply that the fidelity of chromosome segregation during neocortex development improved in modern humans after their divergence from Neanderthals. | |||||
出版者 | ||||||
出版者 | American Association for the Advancement of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2375-2548 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/35905187 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1126/sciadv.abn7702 | |||||
権利 | ||||||
権利情報 | © 2022 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.science.org/doi/10.1126/sciadv.abn7702 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |