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JunB is essential for IL-23-dependent pathogenicity of Th17 cells
https://oist.repo.nii.ac.jp/records/288
https://oist.repo.nii.ac.jp/records/2880f0a7b02-22a3-4a60-bfd1-4fbdb4658355
名前 / ファイル | ライセンス | アクション |
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ncomms15628 (1.2 MB)
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Creative Commons Attribution 4.0 International
(http://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | JunB is essential for IL-23-dependent pathogenicity of Th17 cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Hasan, Zafrul
× Hasan, Zafrul× Koizumi, Shin-ichi× Sasaki, Daiki× Yamada, Hayato× Arakaki, Nana× Fujihara, Yoshitaka× Okitsu, Shiho× Shirahata, Hiroki× Ishikawa, Hiroki |
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書誌情報 |
en : Nature Communications 巻 8, p. 15628, 発行日 2017-05-30 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | CD4+ T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at the Rorc locus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells. Junb-deficient T cells fail to induce TH17-mediated autoimmune encephalomyelitis and colitis. However, JunB deficiency does not affect the abundance of gut-resident non-pathogenic TH17 cells. The selective requirement of JunB for IL-23-dependent TH17 pathogenicity suggests that the JunB-dependent pathway may be a therapeutic target for autoimmune diseases. | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28555647 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/ncomms15628 | |||||
権利 | ||||||
権利情報 | © 2017 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/ncomms15628#abstract | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |