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Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota
https://oist.repo.nii.ac.jp/records/869
https://oist.repo.nii.ac.jp/records/8690d26028b-8b3c-4fa0-8e75-38a006ae90a3
名前 / ファイル | ライセンス | アクション |
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Nakashima-2018-Chitin-based barrier immunity a (8.7 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-05-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Chitin-based barrier immunity and its loss predated mucus-colonization by indigenous gut microbiota | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Nakashima, Keisuke
× Nakashima, Keisuke× Kimura, Satoshi× Ogawa, Yu× Watanabe, Soichi× Soma, Satoshi× Kaneko, Toyoji× Yamada, Lixy× Sawada, Hitoshi× Tung, Che-Huang× Lu, Tsai-Ming× Yu, Jr-Kai× Villar-Briones, Alejandro× Kikuchi, Sakura× Satoh, Noriyuki |
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書誌情報 |
en : Nature Communications 巻 9, 号 1, p. 3402, 発行日 2018-08-24 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Mammalian gut microbiota are integral to host health. However, how this association began remains unclear. We show that in basal chordates the gut space is radially compartmentalized into a luminal part where food microbes pass and an almost axenic peripheral part, defined by membranous delamination of the gut epithelium. While this membrane, framed with chitin nanofibers, structurally resembles invertebrate peritrophic membranes, proteome supports its affinity to mammalian mucus layers, where gut microbiota colonize. In ray-finned fish, intestines harbor indigenous microbes, but chitinous membranes segregate these luminal microbes from the surrounding mucus layer. These data suggest that chitin-based barrier immunity is an ancient system, the loss of which, at least in mammals, provided mucus layers as a novel niche for microbial colonization. These findings provide a missing link for intestinal immune systems in animals, revealing disparate mucosal environment in model organisms and highlighting the loss of a proven system as innovation. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30143642 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-018-05884-0 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-018-05884-0 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |