WEKO3
アイテム
{"_buckets": {"deposit": "34818a26-8522-423e-9a8d-032ad359b2ea"}, "_deposit": {"created_by": 28, "id": "990", "owners": [28], "pid": {"revision_id": 0, "type": "depid", "value": "990"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00000990", "sets": ["89"]}, "author_link": ["5445", "5446", "5443", "5444", "5442", "5447"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-10-31", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "46", "bibliographicPageEnd": "E10940", "bibliographicPageStart": "E10934", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{}, {"bibliographic_title": "Proceedings of the National Academy of Sciences", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Jayawardena, Nadishka"}], "nameIdentifiers": [{"nameIdentifier": "5442", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Burga, Laura N."}], "nameIdentifiers": [{"nameIdentifier": "5443", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Easingwood, Richard A."}], "nameIdentifiers": [{"nameIdentifier": "5444", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takizawa, Yoshimasa"}], "nameIdentifiers": [{"nameIdentifier": "5445", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wolf, Matthias"}], "nameIdentifiers": [{"nameIdentifier": "5446", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bostina, Mihnea"}], "nameIdentifiers": [{"nameIdentifier": "5447", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Recently, the use of oncolytic viruses in cancer therapy has become a realistic therapeutic option. Seneca Valley Virus (SVV) is a newly discovered picornavirus, which has earned a significant reputation as a potent oncolytic agent. Anthrax toxin receptor 1 (ANTXR1), one of the cellular receptors for the protective antigen secreted by Bacillus anthracis, has been identified as the high-affinity cellular receptor for SVV. Here, we report the structure of the SVV-ANTXR1 complex determined by single-particle cryo-electron microscopy analysis at near-atomic resolution. This is an example of a shared receptor structure between a mammalian virus and a bacterial toxin. Our structure shows that ANTXR1 decorates the outer surface of the SVV capsid and interacts with the surface-exposed BC loop and loop II of VP1, \"the puff\" of VP2 and \"the knob\" of VP3. Comparison of the receptor-bound capsid structure with the native capsid structure reveals that receptor binding induces minor conformational changes in SVV capsid structure, suggesting the role of ANTXR1 as an attachment receptor. Furthermore, our results demonstrate that the capsid footprint on the receptor is not conserved in anthrax toxin receptor 2 (ANTXR2), thereby providing a molecular mechanism for explaining the exquisite selectivity of SVV for ANTXR1.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "National Academy of Sciences"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/30381454", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1073/pnas.1810664115", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.pnas.org/content/115/46/E10934", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2018 the Author(s)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0027-8424", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "1091-6490", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Jayawardena-2018-Structural basis for anthrax.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons\nAttribution-NonCommercial-NoDerivatives 4.0 International\n(https://creativecommons.org/licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "Jayawardena-2018-Structural basis for anthrax", "url": "https://oist.repo.nii.ac.jp/record/990/files/Jayawardena-2018-Structural basis for anthrax.pdf"}, "version_id": "b7b2ab8b-567c-4a1b-962e-73f08d7f2ec9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "28", "path": ["89"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/990", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-07-05"}, "publish_date": "2019-07-05", "publish_status": "0", "recid": "990", "relation": {}, "relation_version_is_last": true, "title": ["Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus"], "weko_shared_id": 28}
Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus
https://oist.repo.nii.ac.jp/records/990
https://oist.repo.nii.ac.jp/records/99051b24845-e516-4a50-9c23-007aea8266e3
名前 / ファイル | ライセンス | アクション |
---|---|---|
Jayawardena-2018-Structural basis for anthrax (2.4 MB)
|
Creative Commons
Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-07-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Jayawardena, Nadishka
× Jayawardena, Nadishka× Burga, Laura N.× Easingwood, Richard A.× Takizawa, Yoshimasa× Wolf, Matthias× Bostina, Mihnea |
|||||
書誌情報 |
en : Proceedings of the National Academy of Sciences 巻 115, 号 46, p. E10934-E10940, 発行日 2018-10-31 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Recently, the use of oncolytic viruses in cancer therapy has become a realistic therapeutic option. Seneca Valley Virus (SVV) is a newly discovered picornavirus, which has earned a significant reputation as a potent oncolytic agent. Anthrax toxin receptor 1 (ANTXR1), one of the cellular receptors for the protective antigen secreted by Bacillus anthracis, has been identified as the high-affinity cellular receptor for SVV. Here, we report the structure of the SVV-ANTXR1 complex determined by single-particle cryo-electron microscopy analysis at near-atomic resolution. This is an example of a shared receptor structure between a mammalian virus and a bacterial toxin. Our structure shows that ANTXR1 decorates the outer surface of the SVV capsid and interacts with the surface-exposed BC loop and loop II of VP1, "the puff" of VP2 and "the knob" of VP3. Comparison of the receptor-bound capsid structure with the native capsid structure reveals that receptor binding induces minor conformational changes in SVV capsid structure, suggesting the role of ANTXR1 as an attachment receptor. Furthermore, our results demonstrate that the capsid footprint on the receptor is not conserved in anthrax toxin receptor 2 (ANTXR2), thereby providing a molecular mechanism for explaining the exquisite selectivity of SVV for ANTXR1. | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-8424 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30381454 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1073/pnas.1810664115 | |||||
権利 | ||||||
権利情報 | © 2018 the Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/content/115/46/E10934 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |