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Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons
https://oist.repo.nii.ac.jp/records/1013
https://oist.repo.nii.ac.jp/records/10139567eaf0-71b1-4e42-a492-ea69f8073aac
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S0197018618302900-main (2.1 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zhang, Xinjian
× Zhang, Xinjian× Nagai, Taku× Ahammad, Rijwan Uddin× Kuroda, Keisuke× Nakamuta, Shinichi× Nakano, Takashi× Yukinawa, Naoto× Funahashi, Yasuhiro× Yamahashi, Yukie× Amano, Mutsuki× Yoshimoto, Junichiro× Yamada, Kiyofumi× Kaibuchi, Kozo |
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書誌情報 |
en : Neurochemistry International 巻 122, p. 8-18, 発行日 2018-10-15 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor (D2R) are major components of the striatum. Stimulation of D1R activates protein kinase A (PKA) through Golf to increase neuronal activity, while D2R stimulation inhibits PKA through Gi. Adenosine A2A receptor (A2AR) coupled to Golf is highly expressed in D2R-MSNs within the striatum. However, how dopamine and adenosine co-operatively regulate PKA activity remains largely unknown. Here, we measured Rap1gap serine 563 phosphorylation to monitor PKA activity and examined dopamine and adenosine signals in MSNs. We found that a D1R agonist increased Rap1gap phosphorylation in striatal slices and in D1R-MSNs in vivo. A2AR agonist CGS21680 increased Rap1gap phosphorylation, and pretreatment with the D2R agonist quinpirole blocked this effect in striatal slices. D2R antagonist eticlopride increased Rap1gap phosphorylation in D2R-MSNs in vivo, and the effect of eticlopride was blocked by the pretreatment with the A2AR antagonist SCH58261. These results suggest that adenosine positively regulates PKA in D2R-MSNs through A2AR, while this effect is blocked by basal dopamine in vivo. Incorporating computational model analysis, we propose that the shift from D1R-MSNs to D2R-MSNs or vice versa appears to depend predominantly on a change in dopamine concentration. | |||||
出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0197-0186 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30336179 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.neuint.2018.10.008 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0197018618302900 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |