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Orchestrated ensemble activities constitute a hippocampal memory engram
https://oist.repo.nii.ac.jp/records/1180
https://oist.repo.nii.ac.jp/records/1180e1286029-72af-43cb-82db-85c883ea6b85
名前 / ファイル | ライセンス | アクション |
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Ghandour-2019-Orchestrated ensemble activities (6.3 MB)
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Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-17 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Orchestrated ensemble activities constitute a hippocampal memory engram | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Ghandour, Khaled
× Ghandour, Khaled× Ohkawa, Noriaki× Fung, Chi Chung Alan× Asai, Hirotaka× Saitoh, Yoshito× Takekawa, Takashi× Okubo-Suzuki, Reiko× Soya, Shingo× Nishizono, Hirofumi× Matsuo, Mina× Osanai, Makoto× Sato, Masaaki× Ohkura, Masamichi× Nakai, Junichi× Hayashi, Yasunori× Sakurai, Takeshi× Kitamura, Takashi× Fukai, Tomoki× Inokuchi, Kaoru |
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書誌情報 |
en : Nature Communications 巻 10, 号 1, p. 2637, 発行日 2019-06-14 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The brain stores and recalls memories through a set of neurons, termed engram cells. However, it is unclear how these cells are organized to constitute a corresponding memory trace. We established a unique imaging system that combines Ca2+ imaging and engram identification to extract the characteristics of engram activity by visualizing and discriminating between engram and non-engram cells. Here, we show that engram cells detected in the hippocampus display higher repetitive activity than non-engram cells during novel context learning. The total activity pattern of the engram cells during learning is stable across post-learning memory processing. Within a single engram population, we detected several sub-ensembles composed of neurons collectively activated during learning. Some sub-ensembles preferentially reappear during post-learning sleep, and these replayed sub-ensembles are more likely to be reactivated during retrieval. These results indicate that sub-ensembles represent distinct pieces of information, which are then orchestrated to constitute an entire memory. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31201332 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-019-10683-2 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-019-10683-2#Abs1 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |