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Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect
https://oist.repo.nii.ac.jp/records/1210
https://oist.repo.nii.ac.jp/records/1210bbdf1e80-54a1-4df9-a877-3b62316ece08
名前 / ファイル | ライセンス | アクション |
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Chem comm DZM (3.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-02-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Mang, Dingze
× Mang, Dingze× Zhang, Shijin× Wu, Xia× Hu, Xunwu× Mochizuki, Toshiaki× Li, Guanying× Zhang, Ye |
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書誌情報 |
en : Chemical Communications 巻 55, 号 43, p. 6126-6129, 発行日 2019-05-09 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We designed and synthesized homochiral-peptide-based boron diketonate complexes. Co-administration of the two stereoisomers in cancer cells led to molecular assembly targeting both the plasma membrane and the lysosomes mediated via membrane-bonded enzymes. The dual-targeted-assembly generates a synergistic anticancer effect with amplified cancer spheroid toxicity and enhanced inhibition efficacy on cancer cell migration. | |||||
出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1359-7345 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1364-548X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31070616 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1039/C9CC02715G | |||||
権利 | ||||||
権利情報 | © 2019 The Royal Society of Chemistry | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc02715g#!divAbstract | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |