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States of decay: The systems biology of mRNA stability
https://oist.repo.nii.ac.jp/records/1224
https://oist.repo.nii.ac.jp/records/12241cfa961e-aa43-47e0-bd56-a4dee8697905
名前 / ファイル | ライセンス | アクション |
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Ashworth-2019-States of decay_ The systems bio (1.4 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | States of decay: The systems biology of mRNA stability | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Ashworth, William
× Ashworth, William× Stoney, Patrick N.× Yamamoto, Tadashi |
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書誌情報 |
en : Current Opinion in Systems Biology 巻 15, p. 48-57, 発行日 2019-03-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | An appropriate equilibrium between transcription and mRNA decay is vital for the function of the cell. The RNA-binding complexes regulating mRNA degradation, such as carbon catabolite repression 4-negative on TATA-less, may also control several other stages of the mRNA life cycle, from transcription to translation. This pleiotropic control complicates the analysis of mRNA stability. Computational models have analysed the mechanisms underlying mRNA turnover and have been used to extract mRNA decay rates from high-throughput data sets. Multiomics studies have clarified the actions of RNA-binding complexes, and such studies allow the evolution of more accurate and complex computational models. This review discusses two complementary aspects of systems biology in the study of mRNA decay—computational modelling of mRNA turnover and recent ‘-omics’ studies of the function of RNA-binding proteins controlling mRNA stability. | |||||
出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2452-3100 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.coisb.2019.03.006 | |||||
権利 | ||||||
権利情報 | © 2019 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2452310019300058 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |