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Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage. \nMATERIAL AND METHODS We investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated. \nRESULTS The presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. 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Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS. \nCONCLUSIONS DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Medical Science International Publishing"}, {"subitem_publisher": "International Scientific Information, Inc."}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/31760404", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.12659/MSM.917207", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.medscimonit.com/abstract/index/idArt/917207", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2019 Med Sci Monit"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1643-3750", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "1234-1010", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Nakajima-2019-Diallyl Disulfide Mitigates DNA.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "Nakajima-2019-Diallyl Disulfide Mitigates DNA", "url": "https://oist.repo.nii.ac.jp/record/1243/files/Nakajima-2019-Diallyl Disulfide Mitigates DNA.pdf"}, "version_id": "6b1e71a2-ce2e-4e96-8a4d-a38df55a9a08"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "30", "path": ["67"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/1243", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-03-09"}, "publish_date": "2020-03-09", "publish_status": "0", "recid": "1243", "relation": {}, "relation_version_is_last": true, "title": ["Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation"], "weko_shared_id": 30}
Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation
https://oist.repo.nii.ac.jp/records/1243
https://oist.repo.nii.ac.jp/records/1243e11aa80b-a3b1-4f64-b674-737c03cfa337
名前 / ファイル | ライセンス | アクション |
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Nakajima-2019-Diallyl Disulfide Mitigates DNA (1.7 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Nakajima, Tetsuo
× Nakajima, Tetsuo× Vares, Guillaume× Ninomiya, Yasuharu× Wang, Bing× Katsube, Takanori× Tanaka, Kaoru× Maruyama, Kouichi× Nenoi, Mitsuru |
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書誌情報 |
en : Medical Science Monitor 巻 25, p. 8920-8927, 発行日 2019-11-24 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BACKGROUND Several factors found in foods are beneficial to human health and they may contribute to radiation protection. Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage. MATERIAL AND METHODS We investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated. RESULTS The presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. An increase in apoptosis in HepG2 cells was induced after irradiation, and this effect was stronger in the presence of DADS than in its absence. In mice, when DADS was administered daily for 3 days prior to irradiation, MN formation in irradiated mice was decreased. The decrease in MN formation in mice was greater with 0.5% DADS compared to 1% DADS. Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS. CONCLUSIONS DADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis. |
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出版者 | ||||||
出版者 | Medical Science International Publishing | |||||
出版者 | ||||||
出版者 | International Scientific Information, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1643-3750 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1234-1010 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31760404 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.12659/MSM.917207 | |||||
権利 | ||||||
権利情報 | © 2019 Med Sci Monit | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.medscimonit.com/abstract/index/idArt/917207 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |