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Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia
https://oist.repo.nii.ac.jp/records/1267
https://oist.repo.nii.ac.jp/records/12670c83666e-ae2f-4399-98f5-a3cc61e4df5d
名前 / ファイル | ライセンス | アクション |
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Liu-2019-Exploring Impaired SERCA Pump-Caused (1.5 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-11 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Exploring Impaired SERCA Pump-Caused Alternation Occurrence in Ischemia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Liu, Jiaqi
× Liu, Jiaqi× Zhao, Xiaoye× Gong, Yinglan× Zhang, Jucheng× Zang, Yunliang× Xia, Ling |
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書誌情報 |
en : Computational and Mathematical Methods in Medicine 巻 2019, p. 1-10, 発行日 2019-11-12 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Impaired sarcoplasmic reticulum (SR) calcium transport ATPase (SERCA) gives rise to Ca(2+) alternans and changes of the Ca2+release amount. These changes in Ca(2+) release amount can reveal the mechanism underlying how the interaction between Ca(2+) release and Ca(2+) uptake induces Ca(2+) alternans. This study of alternans by calculating the values of Ca(2+) release properties with impaired SERCA has not been explored before. Here, we induced Ca(2+) alternans by using an impaired SERCA pump under ischemic conditions. The results showed that the recruitment and refractoriness of the Ca(2+) release increased as Ca(2+) alternans occurred. This indicates triggering Ca waves. As the propagation of Ca waves is linked to the occurrence of Ca(2+) alternans, the "threshold" for Ca waves reflects the key factor in Ca(2+) alternans development, and it is still controversial nowadays. We proposed the ratio between the diastolic network SR (NSR) Ca content (Cansr) and the cytoplasmic Ca content (Ca i ) (Cansr/Ca i ) as the "threshold" of Ca waves and Ca(2+) alternans. Diastolic Cansr, Ca i , and their ratio were recorded at the onset of Ca(2+) alternans. Compared with certain Cansr and Ca i , the "threshold" of the ratio can better explain the comprehensive effects of the Ca(2+) release and the Ca(2+) uptake on Ca(2+) alternans onset. In addition, these ratios are related with the function of SERCA pumps, which vary with different ischemic conditions. Thus, values of these ratios could be used to differentiate Ca(2+) alternans from different ischemic cases. This agrees with some experimental results. Therefore, the certain value of diastolic Cansr/Ca i can be the better "threshold" for Ca waves and Ca(2+) alternans. | |||||
出版者 | ||||||
出版者 | Hindawi | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1748-670X | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1748-6718 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31827590 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1155/2019/8237071 | |||||
権利 | ||||||
権利情報 | © 2019 Jiaqi Liu et al. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.hindawi.com/journals/cmmm/2019/8237071/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |