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Error-Speed Correlations in Biopolymer Synthesis
https://oist.repo.nii.ac.jp/records/1270
https://oist.repo.nii.ac.jp/records/12702b3e417c-dfeb-448a-85f4-b71daaac87ea
名前 / ファイル | ライセンス | アクション |
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Chiuchiu-2019-Error-Speed Correlations in Biop (570.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Error-Speed Correlations in Biopolymer Synthesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Chiuchiú, Davide
× Chiuchiú, Davide× Tu, Yuhai× Pigolotti, Simone |
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書誌情報 |
en : Physical Review Letters 巻 123, 号 3, p. 038101, 発行日 2019-07-19 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. The performance of these enzymes is usually characterized in terms of their average error rate and speed. However, because of thermal fluctuations in these single-molecule processes, both error and speed are inherently stochastic quantities. In this Letter, we study fluctuations of error and speed in biopolymer synthesis and show that they are in general correlated. This means that, under equal conditions, polymers that are synthesized faster due to a fluctuation tend to have either better or worse errors than the average. The error-correction mechanism implemented by the enzyme determines which of the two cases holds. For example, discrimination in the forward reaction rates tends to grant smaller errors to polymers with faster synthesis. The opposite occurs for discrimination in monomer rejection rates. Our results provide an experimentally feasible way to identify error-correction mechanisms by measuring the error-speed correlations. | |||||
出版者 | ||||||
出版者 | American Physical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-9007 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1079-7114 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31386470 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1103/PhysRevLett.123.038101 | |||||
権利 | ||||||
権利情報 | © 2019 American Physical Society | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.123.038101 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |