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Rapid Action of Retinoic Acid on the Hypothalamic Pituitary Adrenal Axis
https://oist.repo.nii.ac.jp/records/1274
https://oist.repo.nii.ac.jp/records/127411bc8ce0-a916-4d6f-a7eb-1f1a1a6b186b
名前 / ファイル | ライセンス | アクション |
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Imoesi-2019-Rapid Action of Retinoic Acid on t (1.4 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-03-12 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Rapid Action of Retinoic Acid on the Hypothalamic Pituitary Adrenal Axis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Imoesi, Peter I.
× Imoesi, Peter I.× Bowman, Ellen E.× Stoney, Patrick N.× Matz, Sylwia× McCaffery, Peter |
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書誌情報 |
en : Frontiers in Molecular Neuroscience 巻 12, p. 259, 発行日 2019-10-30 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Retinoic acid (RA) is the active metabolite of vitamin A but is also used as a medication, primarily for acne in which the treatment regime lasts several months. A number of studies have indicated that treatment with RA over this time period impacts the hypothalamic-pituitary-adrenal (HPA) axis and may contribute to a number of the side-effects of the drug. No studies though have investigated the short-term, early effects RA may have on the HPA axis via the transcriptional pathways activated by the RA receptor. This study investigated the action of RA over 3 days on regulatory components of the HPA axis. Several key genes involved in glucocorticoid feedback pathways in the hippocampus, hypothalamus and pituitary were unchanged after 3-days exposure to RA. Key elements though in the adrenal gland involved in corticosterone and aldosterone synthesis were altered in particular with the Cyp11b2 gene downregulated in vivo and ex vivo. The rapid, 5 h, change in Cyp11b2 expression suggested this activation may be direct. These results highlight the adrenal gland as a target of short-term action of RA and potentially a trigger component in the mechanisms by which the long-term adverse effects of RA treatment occur. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5099 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31736706 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fnmol.2019.00259 | |||||
権利 | ||||||
権利情報 | © 2019 Imoesi, Bowman, Stoney, Matz and McCaffery. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fnmol.2019.00259/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |