WEKO3
アイテム
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TNFα Induces Müller Glia to Transition From Non-proliferative Gliosis to a Regenerative Response in Mutant Zebrafish Presenting Chronic Photoreceptor Degeneration
https://oist.repo.nii.ac.jp/records/1344
https://oist.repo.nii.ac.jp/records/13443c9b5a3f-7f14-4888-b529-8ea9c72c2b38
名前 / ファイル | ライセンス | アクション |
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Iribarne-2019-TNFalpha Induces Muller Glia to (7.3 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-02 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | TNFα Induces Müller Glia to Transition From Non-proliferative Gliosis to a Regenerative Response in Mutant Zebrafish Presenting Chronic Photoreceptor Degeneration | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Iribarne, Maria
× Iribarne, Maria× Hyde, David R.× Masai, Ichiro |
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書誌情報 |
en : Frontiers in Cell and Developmental Biology 巻 7, p. 296, 発行日 2019-11-26 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Unlike mammals, zebrafish have the capacity to regenerate neurons in response to damage. Most zebrafish retinal injury models employ acute damage, which is unlike the chronic, gradual damage that occurs in human retinal diseases. Here, we studied the regenerative response in the zebrafish aipl1b mutant, gold rush (gosh). In gosh mutants, both cones and rods degenerate by 3 weeks post-fertilization (wpf). Muller glia do not exhibit a regenerative response by 3 wpf; however, they do present non-proliferative gliosis. Only at 5 wpf, is proliferation of Muller cells and rod precursor cells activated. Rods start to recover at 5 wpf and by 12 wpf they reach a level of recovery comparable to wild type, but cones remain absent in the adult stage. TNFalpha was detected in degenerating cones at 5-7 wpf and in Muller glia at 7 wpf in gosh mutants. At 5 wpf, proliferating Muller glia express Sox2, followed by Pax6 expression in neuronal progenitor cells (NPCs), confirming that the neuronal regeneration program is activated in gosh mutants after 5 wpf. Although acute light-induced damage did not activate proliferation of Muller glia, TNFalpha injection caused Muller glia to commence a proliferative response at 3 wpf in gosh mutants. These results suggest that Muller glia transition from non-proliferative gliosis to a regenerative state in gosh mutants, and that ectopic introduction of TNFalpha promotes this Muller cell transition even at 3 wpf. Thus, zebrafish gosh mutants provide a useful model to investigate mechanisms underlying retinal regeneration in a chronic photoreceptor degeneration model. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2296-634X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31998714 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fcell.2019.00296 | |||||
権利 | ||||||
権利情報 | © 2019 Iribarne, Hyde and Masai. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fcell.2019.00296/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |