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Assembly of heteropolymers via a network of reaction coordinates
https://oist.repo.nii.ac.jp/records/1399
https://oist.repo.nii.ac.jp/records/139987661752-2a5a-4538-a915-62c9b8ccc86c
名前 / ファイル | ライセンス | アクション |
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Chiuchiu-2019-Assembly of heteropolymers via a (746.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Assembly of heteropolymers via a network of reaction coordinates | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Chiuchiù, Davide
× Chiuchiù, Davide× Ferrare, James× Pigolotti, Simone |
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書誌情報 |
en : Physical Review E 巻 100, 号 6, p. 062502, 発行日 2019-12-13 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In biochemistry, heteropolymers encoding biological information are assembled out of equilibrium by sequentially incorporating available monomers found in the environment. Current models of polymerization treat monomer incorporation as a sequence of discrete chemical reactions between intermediate metastable states. In this paper, we use ideas from reaction rate theory and describe nonequilibrium assembly of a heteropolymer via a continuous reaction coordinate. Our approach allows for estimating the copy error and incorporation speed from the Gibbs free energy landscape of the process. We apply our theory to several examples from a simple reaction characterized by a free energy barrier to more complex cases incorporating error correction mechanisms, such as kinetic proofreading. | |||||
出版者 | ||||||
出版者 | American Physical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2470-0045 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2470-0053 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/31962425 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1103/PhysRevE.100.062502 | |||||
権利 | ||||||
権利情報 | ©2019 American Physical Society | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.aps.org/pre/abstract/10.1103/PhysRevE.100.062502 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |