WEKO3
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Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor
https://oist.repo.nii.ac.jp/records/1412
https://oist.repo.nii.ac.jp/records/1412644695f2-ae9c-466b-b153-88fae7eb6a3e
名前 / ファイル | ライセンス | アクション |
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180401CHL1 serum_paper (12.0 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-04-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kotani, Norihiro
× Kotani, Norihiro× Ida, Yui× Nakano, Takanari× Sato, Izumi× Kuwahara, Ryusuke× Yamaguchi, Arisa× Tomita, Masahiro× Honke, Koichi× Murakoshi, Takayuki |
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書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 501, 号 4, p. 982-987, 発行日 2018-05-22 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Close homolog of L1 (CHL1) and its truncated form mainly play crucial roles in mouse brain development and neural functions. Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. Both western blot and direct ELISA analysis revealed that mouse CHL1 level in serum (including serum extracellular vesicles) was significantly elevated in EML4-ALK transgenic mice. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner. Considering these results, the measurement of circulating CHL1 level may contribute to assess a tumor progression in human lung tumor patients. | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/29775614 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.bbrc.2018.05.096 | |||||
権利 | ||||||
権利情報 | © 2018 Elsevier Inc. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S0006291X18311598?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |