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Reinforcement, Dopamine and Rodent Models in Drug Development for ADHD
https://oist.repo.nii.ac.jp/records/1580
https://oist.repo.nii.ac.jp/records/15805635f1f3-028a-42e8-89c8-229e4447e177
名前 / ファイル | ライセンス | アクション |
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Tripp-Wickens2012_Article_ReinforcementDopamineAndRodent(1) (256.8 kB)
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Creative Commons Attribution 2.0 Generic
(https://creativecommons.org/licenses/by/2.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Reinforcement, Dopamine and Rodent Models in Drug Development for ADHD | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Tripp, Gail
× Tripp, Gail× Wickens, Jeff |
|||||
書誌情報 |
en : Neurotherapeutics 巻 9, 号 3, p. 622-634, 発行日 2012-07-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Attention deficit hyperactivity disorder (ADHD) presents special challenges for drug development. Current treatment with psychostimulants and nonstimulants is effective, but their mechanism of action beyond the cellular level is incompletely understood. We review evidence suggesting that altered reinforcement mechanisms are a fundamental characteristic of ADHD. We show that a deficit in the transfer of dopamine signals from established positive reinforcers to cues that predict such reinforcers may underlie these altered reinforcement mechanisms, and in turn explain key symptoms of ADHD. We argue that the neural substrates controlling the excitation and inhibition of dopamine neurons during the transfer process are a promising target for future drug development. There is a need to develop animal models and behavioral paradigms that can be used to experimentally investigate these mechanisms and their effects on sensitivity to reinforcement. More specific and selective targeting of drug development may be possible through this approach. | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1933-7213 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1878-7479 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/22806330 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1007/s13311-012-0132-y | |||||
権利 | ||||||
権利情報 | © 2012 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/2.0 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://link.springer.com/article/10.1007%2Fs13311-012-0132-y | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |