WEKO3
アイテム
{"_buckets": {"deposit": "c407dca5-73c5-44b2-9b1e-71ce86b22ad1"}, "_deposit": {"created_by": 29, "id": "1587", "owners": [29], "pid": {"revision_id": 0, "type": "depid", "value": "1587"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00001587", "sets": ["191"]}, "author_link": ["9517", "9515", "9523", "9516", "9518", "9521", "9520", "9522", "9514", "9519"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-02-20", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "104816", "bibliographicVolumeNumber": "140", "bibliographic_titles": [{}, {"bibliographic_title": "Neurobiology of Disease", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Terenzio, Marco"}], "nameIdentifiers": [{"nameIdentifier": "9514", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Di Pizio, Agostina"}], "nameIdentifiers": [{"nameIdentifier": "9515", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rishal, Ida"}], "nameIdentifiers": [{"nameIdentifier": "9516", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Marvaldi, Letizia"}], "nameIdentifiers": [{"nameIdentifier": "9517", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Di Matteo, Pierluigi"}], "nameIdentifiers": [{"nameIdentifier": "9518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawaguchi, Riki"}], "nameIdentifiers": [{"nameIdentifier": "9519", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Coppola, Giovanni"}], "nameIdentifiers": [{"nameIdentifier": "9520", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Schiavo, Giampietro"}], "nameIdentifiers": [{"nameIdentifier": "9521", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fisher, Elizabeth M.C."}], "nameIdentifiers": [{"nameIdentifier": "9522", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fainzilber, Mike"}], "nameIdentifiers": [{"nameIdentifier": "9523", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "The cytoplasmic dynein motor complex transports essential signals and organelles from the cell periphery to the perinuclear region, hence is critical for the survival and function of highly polarized cells such as neurons. Dynein Light Chain Roadblock-Type 1 (DYNLRB1) is thought to be an accessory subunit required for specific cargos, but here we show that it is essential for general dynein-mediated transport and sensory neuron survival. Homozygous Dynlrb1 null mice are not viable and die during early embryonic development. Furthermore, heterozygous or adult knockdown animals display reduced neuronal growth, and selective depletion of Dynlrb1 in proprioceptive neurons compromises their survival. Conditional depletion of Dynlrb1 in sensory neurons causes deficits in several signaling pathways, including beta-catenin subcellular localization, and a severe impairment in the axonal transport of both lysosomes and retrograde signaling endosomes. Hence, DYNLRB1 is an essential component of the dynein complex, and given dynein\u0027s critical functions in neuronal physiology, DYNLRB1 could have a prominent role in the etiology of human neurodegenerative diseases.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/32088381", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.nbd.2020.104816", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://creativecommons.org/licenses/by-nc-nd/4.0/"}]}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.nbd.2020.104816", "subitem_relation_type_select": "DOI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2020 The Authors."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0969-9961", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-06-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "1-s2.0-S0969996120300917-main.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "1-s2.0-S0969996120300917-main", "url": "https://oist.repo.nii.ac.jp/record/1587/files/1-s2.0-S0969996120300917-main.pdf"}, "version_id": "337dd8ae-0961-4f02-8b67-10431debdc06"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "DYNLRB1 is essential for dynein mediated transport and neuronal survival", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "DYNLRB1 is essential for dynein mediated transport and neuronal survival", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "29", "path": ["191"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/1587", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-06-25"}, "publish_date": "2020-06-25", "publish_status": "0", "recid": "1587", "relation": {}, "relation_version_is_last": true, "title": ["DYNLRB1 is essential for dynein mediated transport and neuronal survival"], "weko_shared_id": 29}
DYNLRB1 is essential for dynein mediated transport and neuronal survival
https://oist.repo.nii.ac.jp/records/1587
https://oist.repo.nii.ac.jp/records/158749db09be-5a0f-4144-925b-7c13df059e2b
名前 / ファイル | ライセンス | アクション |
---|---|---|
1-s2.0-S0969996120300917-main (2.8 MB)
|
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-06-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | DYNLRB1 is essential for dynein mediated transport and neuronal survival | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Terenzio, Marco
× Terenzio, Marco× Di Pizio, Agostina× Rishal, Ida× Marvaldi, Letizia× Di Matteo, Pierluigi× Kawaguchi, Riki× Coppola, Giovanni× Schiavo, Giampietro× Fisher, Elizabeth M.C.× Fainzilber, Mike |
|||||
書誌情報 |
en : Neurobiology of Disease 巻 140, p. 104816, 発行日 2020-02-20 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The cytoplasmic dynein motor complex transports essential signals and organelles from the cell periphery to the perinuclear region, hence is critical for the survival and function of highly polarized cells such as neurons. Dynein Light Chain Roadblock-Type 1 (DYNLRB1) is thought to be an accessory subunit required for specific cargos, but here we show that it is essential for general dynein-mediated transport and sensory neuron survival. Homozygous Dynlrb1 null mice are not viable and die during early embryonic development. Furthermore, heterozygous or adult knockdown animals display reduced neuronal growth, and selective depletion of Dynlrb1 in proprioceptive neurons compromises their survival. Conditional depletion of Dynlrb1 in sensory neurons causes deficits in several signaling pathways, including beta-catenin subcellular localization, and a severe impairment in the axonal transport of both lysosomes and retrograde signaling endosomes. Hence, DYNLRB1 is an essential component of the dynein complex, and given dynein's critical functions in neuronal physiology, DYNLRB1 could have a prominent role in the etiology of human neurodegenerative diseases. | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0969-9961 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32088381 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.nbd.2020.104816 | |||||
権利 | ||||||
権利情報 | © 2020 The Authors. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.nbd.2020.104816 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |