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The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
https://oist.repo.nii.ac.jp/records/1608
https://oist.repo.nii.ac.jp/records/160852843ff2-c1f4-4f70-9e3c-f879376b9d76
名前 / ファイル | ライセンス | アクション |
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e201900494.full (8.4 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-07-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Takahashi, Akinori
× Takahashi, Akinori× Suzuki, Toru× Soeda, Shou× Takaoka, Shohei× Kobori, Shungo× Yamaguchi, Tomokazu× Mohamed, Haytham Mohamed Aly× Yanagiya, Akiko× Abe, Takaya× Shigeta, Mayo× Furuta, Yasuhide× Kuba, Keiji× Yamamoto, Tadashi |
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書誌情報 |
en : Life Science Alliance 巻 3, 号 5, p. e201900494, 発行日 2020-04-01 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver. Liver-specific disruption of Cnot1, encoding a scaffold subunit of the CCR4-NOT complex, leads to increased levels of mRNAs for transcription factors, cell cycle regulators, and DNA damage response-related proteins because of reduced deadenylation and stabilization of these mRNAs. CNOT1 suppression also results in an increase of immature, unspliced mRNAs (pre-mRNAs) for apoptosis-related and inflammation-related genes and promotes RNA polymerase II loading on their promoter regions. In contrast, mRNAs encoding metabolic enzymes become less abundant, concomitant with decreased levels of these pre-mRNAs. Lethal hepatitis develops concomitantly with abnormal mRNA expression. Mechanistically, the CCR4-NOT complex targets and destabilizes mRNAs mainly through its association with Argonaute 2 (AGO2) and butyrate response factor 1 (BRF1) in the liver. Therefore, the CCR4-NOT complex contributes to liver homeostasis by modulating the liver transcriptome through mRNA deadenylation. | |||||
出版者 | ||||||
出版者 | Life Science Alliance | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2575-1077 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32238456 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.26508/lsa.201900494 | |||||
権利 | ||||||
権利情報 | © 2020 Takahashi et al. | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.life-science-alliance.org/content/3/5/e201900494 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |