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Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers
https://oist.repo.nii.ac.jp/records/1699
https://oist.repo.nii.ac.jp/records/169985f1b4ef-a59e-420b-998c-03ed3d7aea42
名前 / ファイル | ライセンス | アクション |
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Manuscrit BNCT 2020-02 (446.4 kB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-09-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Vares, Guillaume
× Vares, Guillaume× Jallet, Vincent× Matsumoto, Yoshitaka× Rentier, Cedric× Takayama, Kentaro× Sasaki, Toshio× Hayashi, Yoshio× Kumada, Hiroaki× Sugawara, Hirotaka |
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書誌情報 |
en : Nanomedicine: Nanotechnology, Biology and Medicine 巻 27, p. 102195, 発行日 2020-04-08 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Treatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron capture therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with gadolinium for magnetic resonance imaging (MRI) in vivo. Chondrosarcoma cells were exposed in vitro to an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers. | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1549-9634 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32278101 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.nano.2020.102195 | |||||
権利 | ||||||
権利情報 | This article/chapter was published in Journal of Nanomedicine: Nanotechnology, Biology and Medicine, Volume 27, Guillaume Vares, Vincent Jallet, Yoshitaka Matsumoto, Cedric Rentier, Kentaro Takayama, Toshio Sasaki, Yoshio Hayashi, Hiroaki Kumada, Hirotaka Sugawara, Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers, 102195, © Elsevier 2020. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S1549963420300496?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |