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A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection
https://oist.repo.nii.ac.jp/records/1711
https://oist.repo.nii.ac.jp/records/17112755d707-6227-4769-ae54-0d93d802b529
名前 / ファイル | ライセンス | アクション |
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Girard-2020-A biologically constrained spiking (3.0 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | action selection | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | basal ganglia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | centromedian/parafascicular thalamus | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | computational model | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | monkey | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Girard, Benoît
× Girard, Benoît× Lienard, Jean× Gutierrez, Carlos Enrique× Delord, Bruno× Doya, Kenji |
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書誌情報 |
en : European Journal of Neuroscience 発行日 2020-07-03 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Action selection has been hypothesized to be a key function of the basal ganglia, yet the nuclei involved, their interactions and the importance of the direct/indirect pathway segregation in such process remain debated. Here, we design a spiking computational model of the monkey basal ganglia derived from a previously published population model, initially parameterized to reproduce electrophysiological activity at rest and to embody as much quantitative anatomical data as possible. As a particular feature, both models exhibit the strong overlap between the direct and indirect pathways that has been documented in non-human primates. Here, we first show how the translation from a population to an individual neuron model was achieved, with the addition of a minimal number of parameters. We then show that our model performs action selection, even though it was built without any assumption on the activity carried out during behaviour. We investigate the mechanisms of this selection through circuit disruptions and found an instrumental role of the off-centre/on-surround structure of the MSN-STN-GPi circuit, as well as of the MSN-MSN and FSI-MSN projections. This validates their potency in enabling selection. We finally study the pervasive centromedian and parafascicular thalamic inputs that reach all basal ganglia nuclei and whose influence is therefore difficult to anticipate. Our model predicts that these inputs modulate the responsiveness of action selection, making them a candidate for the regulation of the speed-accuracy trade-off during decision-making. | |||||
出版者 | ||||||
出版者 | Federation of European Neuroscience Societies | |||||
出版者 | ||||||
出版者 | John Wiley & Sons Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0953-816X | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1460-9568 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32564449 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/ejn.14869 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/ejn.14869 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |