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A high-coverage Neandertal genome from Chagyrskaya Cave
https://oist.repo.nii.ac.jp/records/1722
https://oist.repo.nii.ac.jp/records/17223539fb39-1ca8-44ed-ad2e-81d845c06153
名前 / ファイル | ライセンス | アクション |
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15132.full-1 (1.7 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A high-coverage Neandertal genome from Chagyrskaya Cave | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Mafessoni, Fabrizio
× Mafessoni, Fabrizio× Grote, Steffi× de Filippo, Cesare× Slon, Viviane× Kolobova, Kseniya A.× Viola, Bence× Markin, Sergey V.× Chintalapati, Manjusha× Peyrégne, Stephane× Skov, Laurits× Skoglund, Pontus× Krivoshapkin, Andrey I.× Derevianko, Anatoly P.× Meyer, Matthias× Kelso, Janet× Peter, Benjamin× Prüfer, Kay× Pääbo, Svante |
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書誌情報 |
en : Proceedings of the National Academy of Sciences 巻 117, 号 26, p. 15132-15136, 発行日 2020-06-16 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | We sequenced the genome of a Neandertal from Chagyrskaya Cave in the Altai Mountains, Russia, to 27-fold genomic coverage. We show that this Neandertal was a female and that she was more related to Neandertals in western Eurasia [Prufer et al., Science 358, 655-658 (2017); Hajdinjak et al., Nature 555, 652-656 (2018)] than to Neandertals who lived earlier in Denisova Cave [Prufer et al., Nature 505, 43-49 (2014)], which is located about 100 km away. About 12.9% of the Chagyrskaya genome is spanned by homozygous regions that are between 2.5 and 10 centiMorgans (cM) long. This is consistent with the fact that Siberian Neandertals lived in relatively isolated populations of less than 60 individuals. In contrast, a Neandertal from Europe, a Denisovan from the Altai Mountains, and ancient modern humans seem to have lived in populations of larger sizes. The availability of three Neandertal genomes of high quality allows a view of genetic features that were unique to Neandertals and that are likely to have been at high frequency among them. We find that genes highly expressed in the striatum in the basal ganglia of the brain carry more amino-acid-changing substitutions than genes expressed elsewhere in the brain, suggesting that the striatum may have evolved unique functions in Neandertals. | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-8424 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1091-6490 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32546518 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1073/pnas.2004944117 | |||||
権利 | ||||||
権利情報 | © 2020 the Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.pnas.org/content/117/26/15132 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |