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The Neandertal Progesterone Receptor
https://oist.repo.nii.ac.jp/records/1723
https://oist.repo.nii.ac.jp/records/17236b61f769-191b-45c4-9566-a496f7458ba3
名前 / ファイル | ライセンス | アクション |
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msaa119-1 (424.3 kB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Neandertal Progesterone Receptor | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | progesterone receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neandertals | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fertility | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PROGINS | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zeberg, Hugo
× Zeberg, Hugo× Kelso, Janet× Pääbo, Svante |
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書誌情報 |
en : Molecular Biology and Evolution 巻 37, 号 9, p. 2655-2660, 発行日 2020-05-21 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The hormone progesterone is important for preparing the uterine lining for egg implantation and for maintaining the early stages of pregnancy. The gene encoding the progesterone receptor (PGR) carries introgressed Neandertal haplotypes with two missense substitutions and a mobile Alu element. These Neandertal gene variants have reached nearly 20% frequency in non-Africans and have been associated with preterm birth. Here, we show that one of the missense substitutions appears fixed in Neandertals, while the other substitution as well as the Alu insertion were polymorphic among Neandertals. We show that two Neandertal haplotypes carrying the PGR gene entered the modern human population and that present-day carriers of the Neandertal haplotypes express higher levels of the receptor. In a cohort of present-day Britons, these carriers have more siblings, fewer miscarriages, and less bleeding during early pregnancy suggesting that the Neandertal progesterone receptor alleles promote fertility. This may explain their high frequency in modern human populations. | |||||
出版者 | ||||||
出版者 | Oxford University Press on behalf of the Society for Molecular Biology and Evolution | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0737-4038 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1537-1719 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32437543 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1093/molbev/msaa119 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/molbev/msaa119 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |