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Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus
https://oist.repo.nii.ac.jp/records/1740
https://oist.repo.nii.ac.jp/records/174082fd22c8-bca8-489f-bda9-12829d2c4c8d
名前 / ファイル | ライセンス | アクション |
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Sato-2020-Distinct Mechanisms of Over-Represen (5.3 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International(https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | two-photon imaging | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | G-CaMP7 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | spatial navigation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cognitive map | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | spatial learning | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | memory | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Shank | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | synapses | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hippocampal CA1 region | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neurodevelopmental disorders | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Sato, Masaaki
× Sato, Masaaki× Mizuta, Kotaro× Islam, Tanvir× Kawano, Masako× Sekine, Yukiko× Takekawa, Takashi× Gomez-Dominguez, Daniel× Schmidt, Alexander× Wolf, Fred× Kim, Karam× Yamakawa, Hiroshi× Ohkura, Masamichi× Lee, Min Goo× Fukai, Tomoki× Nakai, Junichi× Hayashi, Yasunori |
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書誌情報 |
en : Cell Reports 巻 32, 号 1, p. 107864, 発行日 2020-07-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but the cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate in virtual reality, we find that the over-representation of reward and landmark locations are mediated by persistent and separable subsets of neurons, with distinct time courses of emergence and differing underlying molecular mechanisms. Strikingly, we find that in mice lacking Shank2, an autism spectrum disorder (ASD)-linked gene encoding an excitatory postsynaptic scaffold protein, the learning-induced over-representation of landmarks was absent whereas the over-representation of rewards was substantially increased, as was goal-directed behavior. These findings demonstrate that multiple hippocampal coding processes for unique types of salient features are distinguished by a Shank2-dependent mechanism and suggest that abnormally distorted hippocampal salience mapping may underlie cognitive and behavioral abnormalities in a subset of ASDs. | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32640229 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2020.107864 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2211124720308457 |