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Firing rate-dependent phase responses of Purkinje cells support transient oscillations
https://oist.repo.nii.ac.jp/records/1788
https://oist.repo.nii.ac.jp/records/17881585244a-d0b3-48df-80c8-8b42a43b838f
名前 / ファイル | ライセンス | アクション |
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elife-60692-v1 (2.4 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Firing rate-dependent phase responses of Purkinje cells support transient oscillations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Purkinje cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | phase response curve | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | rate adaptation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | reciprocal inhibition | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | network oscillations | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transient assembly | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Zang, Yunliang
× Zang, Yunliang× Hong, Sungho× De Schutter, Erik |
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書誌情報 |
en : eLife 巻 9, p. e60692, 発行日 2020-09-08 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model, we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na(+) channels. Then, we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/32895121 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.60692 | |||||
権利 | ||||||
権利情報 | © 2020 Zang et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/60692 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |