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Changes in gene DNA methylation and expression networks accompany caste specialization and age‐related physiological changes in a social insect
https://oist.repo.nii.ac.jp/records/1807
https://oist.repo.nii.ac.jp/records/180720d07b97-6387-4f98-926d-1f093a42f854
名前 / ファイル | ライセンス | アクション |
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Morandin_et_al-1 (980.1 kB)
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Creative Commons Attribution-NonCommercial 4.0 International(https://creativecommons.org/licenses/by-nc/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-11-20 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Changes in gene DNA methylation and expression networks accompany caste specialization and age‐related physiological changes in a social insect | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ageing | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | caste | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | co‐expression network | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | co‐methylation network | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | phenotypic plasticity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Morandin, Claire
× Morandin, Claire× Brendel, Volker P.× Sundström, Liselotte× Helanterä, Heikki× Mikheyev, Alexander S. |
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書誌情報 |
en : Molecular Ecology 巻 28, 号 8, p. 1975-1993, 発行日 2019-04-29 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Social insects provide systems for studying epigenetic regulation of phenotypes, particularly with respect to differentiation of reproductive and worker castes, which typically arise from a common genetic background. The role of gene expression in caste specialization has been extensively studied, but the role of DNA methylation remains controversial. Here, we perform well-replicated, integrated analyses of DNA methylation and gene expression in brains of an ant (Formica exsecta) with distinct female castes using traditional approaches (tests of differential methylation) combined with a novel approach (analysis of co-expression and co-methylation networks). We found differences in expression and methylation profiles between workers and queens at different life stages, as well as some overlap between DNA methylation and expression at the functional level. Large portions of the transcriptome and methylome are organized into‘modules’of genes, some significantly associated with phenotypic traits of castes and developmental stages. Several gene co-expression modules are preserved in co-methylation networks, consistent with possible regulation of caste-specific gene expression by DNA methylation. Surprisingly, brain co-expression modules were highly preserved when compared with a previous study that examined whole-body co-expression patterns in 16 ant species (Morandin et al. 2016), suggesting that these modules are evolutionarily conserved and for specific functions in various tissues. Altogether, these results suggest that DNA methylation participates in regulation of caste specialization and age-related physiological changes in social insects. | |||||
出版者 | ||||||
出版者 | John Wiley & Sons | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0962-1083 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1365-294X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30809873 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/mec.15062 | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: Morandin, C, Brendel, VP, Sundström, L, Helanterä, H, Mikheyev, AS. Changes in gene DNA methylation and expression networks accompany caste specialization and age‐related physiological changes in a social insect. Mol Ecol. 2019; 28: 1975– 1993., which has been published in final form at https://doi.org/10.1111/mec.15062. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/mec.15062 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://researchportal.helsinki.fi/en/publications/changes-in-gene-dna-methylation-and-expression-networks-accompany | |||||
関連名称 | University of Helsinki | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |