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Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development
https://oist.repo.nii.ac.jp/records/1844
https://oist.repo.nii.ac.jp/records/1844a19f9b45-a54a-492c-beed-921ae01bab12
名前 / ファイル | ライセンス | アクション |
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Suzuki-2020-Regulation of Fetal Genes by Trans (2.2 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Regulation of Fetal Genes by Transitions among RNA-Binding Proteins during Liver Development | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RNA binding proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fetal liver genes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ccr4-not complex | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Suzuki, Toru
× Suzuki, Toru× Adachi, Shungo× Kikuguchi, Chisato× Shibata, Shinsuke× Nishijima, Saori× Kawamoto, Yurie× Iizuka, Yusuke× Koseki, Haruhiko× Okano, Hideyuki× Natsume, Tohru× Yamamoto, Tadashi |
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書誌情報 |
en : International Journal of Molecular Sciences 巻 21, 号 23, p. 9319, 発行日 2020-12-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Transcripts of alpha-fetoprotein (Afp), H19, and insulin-like growth factor 2 (Igf2) genes are highly expressed in mouse fetal liver, but decrease drastically during maturation. While transcriptional regulation of these genes has been well studied, the post-transcriptional regulation of their developmental decrease is poorly understood. Here, we show that shortening of poly(A) tails and subsequent RNA decay are largely responsible for the postnatal decrease of Afp, H19, and Igf2 transcripts in mouse liver. IGF2 mRNA binding protein 1 (IMP1), which regulates stability and translation efficiency of target mRNAs, binds to these fetal liver transcripts. When IMP1 is exogenously expressed in mouse adult liver, fetal liver transcripts show higher expression and possess longer poly(A) tails, suggesting that IMP1 stabilizes them. IMP1 declines concomitantly with fetal liver transcripts as liver matures. Instead, RNA-binding proteins (RBPs) that promote RNA decay, such as cold shock domain containing protein E1 (CSDE1), K-homology domain splicing regulatory protein (KSRP), and CUG-BP1 and ETR3-like factors 1 (CELF1), bind to 3′ regions of fetal liver transcripts. These data suggest that transitions among RBPs associated with fetal liver transcripts shift regulation from stabilization to decay, leading to a postnatal decrease in those fetal transcripts. | |||||
出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1422-0067 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1661-6596 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33297405 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3390/ijms21239319 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/1422-0067/21/23/9319 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |