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The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action
https://oist.repo.nii.ac.jp/records/1864
https://oist.repo.nii.ac.jp/records/186425f7b668-71d5-43c7-8dd3-905494f556ea
名前 / ファイル | ライセンス | アクション |
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Dudysová-2020-The Effects of Daytime Psilocybi (1.2 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neuroplasticity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | EEG power spectra | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | antidepressant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | psilocybin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | sleep | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rapid Eye Movement sleep | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rapid Eye Movement latency | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | slow-wave (delta-wave) sleep | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Dudysová, Daniela
× Dudysová, Daniela× Janků, Karolina× Šmotek, Michal× Saifutdinova, Elizaveta× Kopřivová, Jana× Bušková, Jitka× Mander, Bryce Anthony× Brunovský, Martin× Zach, Peter× Korčák, Jakub× Andrashko, Veronika× Viktorinová, Michaela× Tylš, Filip× Bravermanová, Anna× Froese, Tom× Páleníček, Tomáš× Horáček, Jiří |
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書誌情報 |
en : Frontiers in Pharmacology 巻 11, p. 602590, 発行日 2020-12-03 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin’s antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the effect of psilocybin on sleep architecture on the night after psilocybin administration. Regarding the potential antidepressant properties, we hypothesized that psilocybin, similar to other classical antidepressants, would reduce rapid eye movement (REM) sleep and prolong REM sleep latency. Moreover, we also hypothesized that psilocybin would promote slow-wave activity (SWA) expression in the first sleep cycle, a marker of sleep-related neuroplasticity. Twenty healthy volunteers (10 women, age 28–53) underwent two drug administration sessions, psilocybin or placebo, in a randomized, double-blinded design. Changes in sleep macrostructure, SWA during the first sleep cycle, whole night EEG spectral power across frequencies in non-rapid eye movement (NREM) and REM sleep, and changes in subjective sleep measures were analyzed. The results revealed prolonged REM sleep latency after psilocybin administration and a trend toward a decrease in overall REM sleep duration. No changes in NREM sleep were observed. Psilocybin did not affect EEG power spectra in NREM or REM sleep when examined across the whole night. However, psilocybin suppressed SWA in the first sleep cycle. No evidence was found for sleep-related neuroplasticity, however, a different dosage, timing, effect on homeostatic regulation of sleep, or other mechanisms related to antidepressant effects may play a role. Overall, this study suggests that potential antidepressant properties of psilocybin might be related to changes in sleep. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1663-9812 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33343372 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fphar.2020.602590 | |||||
権利 | ||||||
権利情報 | © 2020 Dudysová, Janků, Šmotek, Saifutdinova, Kopřivová, Bušková, Mander, Brunovský, Zach, Korčák, Andrashko, Viktorinová, Tylš, Bravermanová, Froese, Páleníček and Horáček. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fphar.2020.602590/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |