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Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards
https://oist.repo.nii.ac.jp/records/1903
https://oist.repo.nii.ac.jp/records/1903c8fd12b7-17e6-4cab-be98-3dbc68cc9767
名前 / ファイル | ライセンス | アクション |
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Miyazaki-2020-Serotonergic projections to the (4.2 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-20 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Miyazaki, Katsuhiko
× Miyazaki, Katsuhiko× Miyazaki, Kayoko W.× Sivori, Gaston× Yamanaka, Akihiro× Tanaka, Kenji F.× Doya, Kenji |
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書誌情報 |
en : Science Advances 巻 6, 号 48, p. eabc7246, 発行日 2020-11-27 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Optogenetic activation of serotonergic neurons in the dorsal raphe nucleus (DRN) enhances patience when waiting for future rewards, and this effect is maximized by both high probability and high timing uncertainty of reward. Here, we explored which serotonin projection areas contribute to these effects using optogenetic axon terminal stimulation. We found that serotonin stimulation in the orbitofrontal cortex (OFC) is nearly as effective as that in the DRN for promoting waiting, while in the nucleus accumbens, it does not promote waiting. We also found that serotonin stimulation in the medial prefrontal cortex (mPFC) promotes waiting only when the timing of future rewards is uncertain. Our Bayesian decision model of waiting assumed that the OFC and mPFC calculate the posterior probability of reward delivery separately. These results suggest that serotonin in the mPFC affects evaluation of time committed, while serotonin in the OFC is responsible for overall valuation of delayed rewards. | |||||
出版者 | ||||||
出版者 | American Association for the Advancement of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2375-2548 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33246957 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1126/sciadv.abc7246 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s), some rights reserved; exclusive licensee American Association for the Advancement of Science. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://advances.sciencemag.org/content/6/48/eabc7246 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |