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AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication
https://oist.repo.nii.ac.jp/records/1933
https://oist.repo.nii.ac.jp/records/1933b39e5f9e-ae71-43bb-9a79-74158bea2ac5
名前 / ファイル | ライセンス | アクション |
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Yamashiro-2020-AUTS2 Governs Cerebellar Develo (10.9 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Yamashiro, Kunihiko
× Yamashiro, Kunihiko× Hori, Kei× Lai, Esther S.K.× Aoki, Ryo× Shimaoka, Kazumi× Arimura, Nariko× Egusa, Saki F.× Sakamoto, Asami× Abe, Manabu× Sakimura, Kenji× Watanabe, Takaki× Uesaka, Naofumi× Kano, Masanobu× Hoshino, Mikio |
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書誌情報 |
en : iScience 巻 23, 号 12, p. 101820, 発行日 2020-11-18 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Autism susceptibility candidate 2 (AUTS2), a risk gene for autism spectrum disorders (ASDs), is implicated in telencephalon development. Because AUTS2 is also expressed in the cerebellum where defects have been linked to ASDs, we investigated AUTS2 functions in the cerebellum. AUTS2 is specifically localized in Purkinje cells (PCs) and Golgi cells during postnatal development. Auts2 conditional knockout (cKO) mice exhibited smaller and deformed cerebella containing immature-shaped PCs with reduced expression of Cacna1a. Auts2 cKO and knock-down experiments implicated AUTS2 participation in elimination and translocation of climbing fiber synapses and restriction of parallel fiber synapse numbers. Auts2 cKO mice exhibited behavioral impairments in motor learning and vocal communications. Because Cacna1a is known to regulate synapse development in PCs, it suggests that AUTS2 is required for PC maturation to elicit normal development of PC synapses and thus the impairment of AUTS2 may cause cerebellar dysfunction related to psychiatric illnesses such as ASDs. | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2589-0042 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33305180 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.isci.2020.101820 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2589004220310178?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |