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バイオ試薬投与によるがん細胞や微小環境の代謝・形質変化およびその機構の解明
https://doi.org/10.15102/1394.00001791
https://doi.org/10.15102/1394.00001791674a38bc-592d-4d09-ab0a-7cca8b003dfb
名前 / ファイル | ライセンス | アクション |
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Full_Text (53.2 MB)
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Final_Exam_Abstract (42.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2021-03-19 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | バイオ試薬投与によるがん細胞や微小環境の代謝・形質変化およびその機構の解明 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Study on Alteration of Cellular Phenotypes and Processes in Cancer Using Exogenous Biological Agents | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
ID登録 | ||||||||
ID登録 | 10.15102/1394.00001791 | |||||||
ID登録タイプ | JaLC | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 (英) |
Hoh, Hong Huat
× Hoh, Hong Huat
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抄録 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Cellular and genetic heterogeneity contributes to the complexity of cancer which poses challenges for cancer therapy. For instance, epithelial-to-mesenchymal transition (EMT) is a physiological phenomenon that was adopted to neoplasm to describe the possibility of carcinoma cells in acquiring mesenchymal traits, leading to invasion and metastatic dissemination. These EMT-induced tumor cells acquire cancer stem cells (CSCs) properties and contribute to heterogeneity within a tumor microenvironment. My thesis is set out to tackle the abovementioned phenomenon, with a common goal of investigating the potential of using exogenous biological agents in modifying the cellular phenotypes and processes of cancer. Firstly, I demonstrated the molecular mechanism and the ability of altering the stem cell property of breast cancer cells by downregulating CD44 molecules using exogenous miRNAs. Secondly, I investigated the potential of bioinspired laminin-derived self-assembling peptides to alter the microenvironment and cellular processes including metabolism of cancer cells for anti-metastatic treatment in pancreatic cancer. Both studies utilized comprehensive molecular biology approaches in elucidating the functional changes and mechanisms behind the therapeutic effects of biological agents using relevant cancer cell lines and animal xenotransplantation models. This thesis provides insights into cancer cell plasticity which can be harnessed for cancer therapy. | |||||||
言語 | en | |||||||
口頭試問日 | ||||||||
2020-07-30 | ||||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2020-08-31 | |||||||
学位名 | ||||||||
学位名 | Doctor of Philosophy | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第60号 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 38005 | |||||||
学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
権利 | ||||||||
権利情報 | © 2020 The Author. |