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The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning
https://oist.repo.nii.ac.jp/records/2133
https://oist.repo.nii.ac.jp/records/2133b79209f5-4b2f-42f0-96cc-e0d001566d03
名前 / ファイル | ライセンス | アクション |
---|---|---|
Kiyomitsu-2021-The Nuclear Mitotic Apparatus ( (2.0 MB)
|
Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-05-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | NuMA | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | spindle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nuclear formation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | dynein | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ran-GTP | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kiyomitsu, Tomomi
× Kiyomitsu, Tomomi× Boerner, Susan |
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書誌情報 |
en : Frontiers in Cell and Developmental Biology 巻 9, p. 653801, 発行日 2021-04-01 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex. At these locations, NuMA acts as a key structural hub in nuclear formation, spindle assembly, and mitotic spindle positioning, respectively. To achieve its variable functions, NuMA interacts with multiple factors, including DNA, microtubules, the plasma membrane, importins, and cytoplasmic dynein. The binding of NuMA to dynein via its N-terminal domain drives spindle pole focusing and spindle positioning, while multiple interactions through its C-terminal region define its subcellular localizations and functions. In addition, NuMA can self-assemble into high-ordered structures which likely contribute to spindle positioning and nuclear formation. In this review, we summarize recent advances in NuMA’s domains, functions and regulations, with a focus on human NuMA, to understand how and why vertebrate NuMA participates in these functions in comparison with invertebrate NuMA-related proteins. | |||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2296-634X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33869212 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fcell.2021.653801 | |||||
権利 | ||||||
権利情報 | © 2021 Kiyomitsu and Boerner. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fcell.2021.653801/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |