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The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development
https://oist.repo.nii.ac.jp/records/2205
https://oist.repo.nii.ac.jp/records/22050ef16ac4-de58-4843-8508-d675f5ec4579
名前 / ファイル | ライセンス | アクション |
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1-s2.0-S2211124721006616-main (4.3 MB)
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-08-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The CTNNBIP1-CLSTN1 fusion transcript regulates human neocortical development | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fusion transcript | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CTNNBIP1-CLSTN1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cortical expansion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | basal neural progenitor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | outer radial glia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neurogenesis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Wnt/β-catenin signaling | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Ou, Min-Yi
× Ou, Min-Yi× Xiao, Qi× Ju, Xiang-Chun× Zeng, Peng-Ming× Huang, Jing× Sheng, Ai-Li× Luo, Zhen-Ge |
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書誌情報 |
en : Cell Reports 巻 35, 号 13, p. 109290, 発行日 2021-06-29 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Fusion transcripts or RNAs have been found in both disordered and healthy human tissues and cells; however, their physiological functions in the brain development remain unknown. In the analysis of deposited RNA-sequence libraries covering early to middle embryonic stages, we identify 1,055 fusion transcripts present in the developing neocortex. Interestingly, 98 fusion transcripts exhibit distinct expression patterns in various neural progenitors (NPs) or neurons. We focus on CTNNBIP1-CLSTN1 (CTCL), which is enriched in outer radial glial cells that contribute to cortex expansion during human evolution. Intriguingly, downregulation of CTCL in cultured human cerebral organoids causes marked reduction in NPs and precocious neuronal differentiation, leading to impairment of organoid growth. Furthermore, the expression of CTCL fine-tunes Wnt/β-catenin signaling that controls cortex patterning. Together, this work provides evidence indicating important roles of fusion transcript in human brain development and evolution. | |||||
出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34192541 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.celrep.2021.109290 | |||||
権利 | ||||||
権利情報 | © 2021 The Authors. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.sciencedirect.com/science/article/pii/S2211124721006616?via%3Dihub | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |