WEKO3
アイテム
{"_buckets": {"deposit": "339aa241-f7dd-4c77-9778-cd12e65c3719"}, "_deposit": {"created_by": 31, "id": "2242", "owners": [31], "pid": {"revision_id": 0, "type": "depid", "value": "2242"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00002242", "sets": ["67"]}, "author_link": ["14699", "14693", "14696", "14694", "14701", "14688", "14685", "14702", "14698", "14686", "14681", "14683", "14700", "14695", "14692", "14684", "14687", "14691", "14682", "14689", "14697", "14690"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-07-19", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "4379", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{}, {"bibliographic_title": "Nature Communications", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ban, Tatsuma"}], "nameIdentifiers": [{"nameIdentifier": "14681", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikuchi, Masako"}], "nameIdentifiers": [{"nameIdentifier": "14682", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Go R."}], "nameIdentifiers": [{"nameIdentifier": "14683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Manabe, Akio"}], "nameIdentifiers": [{"nameIdentifier": "14684", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tagata, Noriko"}], "nameIdentifiers": [{"nameIdentifier": "14685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Harita, Kayo"}], "nameIdentifiers": [{"nameIdentifier": "14686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiyama, Akira"}], "nameIdentifiers": [{"nameIdentifier": "14687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishimura, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "14688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimi, Ryusuke"}], "nameIdentifiers": [{"nameIdentifier": "14689", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kirino, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "14690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanai, Hideyuki"}], "nameIdentifiers": [{"nameIdentifier": "14691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Yoshiko"}], "nameIdentifiers": [{"nameIdentifier": "14692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "14693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hihara, Hiroe"}], "nameIdentifiers": [{"nameIdentifier": "14694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "14695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsukahara, Kappei"}], "nameIdentifiers": [{"nameIdentifier": "14696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimatsu, Kentaro"}], "nameIdentifiers": [{"nameIdentifier": "14697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "14698", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taniguchi, Tadatsugu"}], "nameIdentifiers": [{"nameIdentifier": "14699", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "14700", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "14701", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tamura, Tomohiko"}], "nameIdentifiers": [{"nameIdentifier": "14702", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, IRF5 activation status during the disease course and the effects of IRF5 inhibition after disease onset are unclear. Here, we show that SLE patients in both the active and remission phase have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of type I interferon signaling in suppressing disease in a mouse model of SLE, possibly due to the function of IRF5 in oxidative phosphorylation. We further demonstrate that inhibition of IRF5 via conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after disease onset suppresses disease progression and is effective for maintenance of remission in mice. These results suggest that IRF5 inhibition might overcome the limitations of current SLE therapies, thus promoting drug discovery research on IRF5 inhibitors.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Nature Portfolio"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/34282144", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41467-021-24609-4", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41467-021-24609-4", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2021 The Author(s)"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-09-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Ban-2021-Genetic and chemical inhibition of IR.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "CC BY 4.0\nCreative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "Ban-2021-Genetic and chemical inhibition of IR", "url": "https://oist.repo.nii.ac.jp/record/2242/files/Ban-2021-Genetic and chemical inhibition of IR.pdf"}, "version_id": "cc431697-7ffb-4fea-8fec-b6d455f8cc32"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "INTERFERON REGULATORY FACTOR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PLASMA-CELLS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "B-CELLS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DENDRITIC CELLS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ALPHA ACTIVITY", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PROTECTS MICE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ERYTHEMATOSUS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PATHOGENESIS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DEFICIENCY", "subitem_subject_scheme": "Other"}, {"subitem_subject": "AUTOIMMUNITY", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "31", "path": ["67"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/2242", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-09-07"}, "publish_date": "2021-09-07", "publish_status": "0", "recid": "2242", "relation": {}, "relation_version_is_last": true, "title": ["Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease"], "weko_shared_id": 31}
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease
https://oist.repo.nii.ac.jp/records/2242
https://oist.repo.nii.ac.jp/records/22420bf4ce6a-910e-4d45-92db-09a93586d56c
名前 / ファイル | ライセンス | アクション |
---|---|---|
Ban-2021-Genetic and chemical inhibition of IR (2.0 MB)
|
CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-09-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | INTERFERON REGULATORY FACTOR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PLASMA-CELLS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | B-CELLS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DENDRITIC CELLS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ALPHA ACTIVITY | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PROTECTS MICE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ERYTHEMATOSUS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PATHOGENESIS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DEFICIENCY | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AUTOIMMUNITY | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Ban, Tatsuma
× Ban, Tatsuma× Kikuchi, Masako× Sato, Go R.× Manabe, Akio× Tagata, Noriko× Harita, Kayo× Nishiyama, Akira× Nishimura, Kenichi× Yoshimi, Ryusuke× Kirino, Yohei× Yanai, Hideyuki× Matsumoto, Yoshiko× Suzuki, Shuichi× Hihara, Hiroe× Ito, Masashi× Tsukahara, Kappei× Yoshimatsu, Kentaro× Yamamoto, Tadashi× Taniguchi, Tadatsugu× Nakajima, Hideaki× Ito, Shuichi× Tamura, Tomohiko |
|||||
書誌情報 |
en : Nature Communications 巻 12, p. 4379, 発行日 2021-07-19 |
|||||
抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, IRF5 activation status during the disease course and the effects of IRF5 inhibition after disease onset are unclear. Here, we show that SLE patients in both the active and remission phase have aberrant activation of IRF5 and interferon-stimulated genes. Partial inhibition of IRF5 is superior to full inhibition of type I interferon signaling in suppressing disease in a mouse model of SLE, possibly due to the function of IRF5 in oxidative phosphorylation. We further demonstrate that inhibition of IRF5 via conditional Irf5 deletion and a newly developed small-molecule inhibitor of IRF5 after disease onset suppresses disease progression and is effective for maintenance of remission in mice. These results suggest that IRF5 inhibition might overcome the limitations of current SLE therapies, thus promoting drug discovery research on IRF5 inhibitors. | |||||
出版者 | ||||||
出版者 | Nature Portfolio | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34282144 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-021-24609-4 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s) | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-021-24609-4 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |