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The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells
https://oist.repo.nii.ac.jp/records/229
https://oist.repo.nii.ac.jp/records/22960be1ec3-1039-482b-b5f4-37e5c91379c9
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-05-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Juxtamembrane Domain of Butyrophilin BTN3A1 Controls Phosphoantigen-Mediated Activation of Human Vγ9Vδ2 T Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者(英) |
Peigné, Cassie-Marie
× Peigné, Cassie-Marie× Léger, Alexandra× Gesnel, Marie-Claude× Konczak, Fabienne× Olive, Daniel× Bonneville, Marc× Breathnach, Richard× Scotet, Emmanuel |
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書誌情報 |
en : The Journal of Immunology 巻 198, 号 11, p. 4228-4234, 発行日 2017-05-22 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells are specifically activated by small phosphorylated metabolites called phosphoantigens (PAg). Stress-induced changes in target cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain. This leads to the activation of Vγ9Vδ2 T cells. In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced γδ T cell reactivity. There is thus a specific requirement for BTN3A1’s juxtamembrane domain for correct γδ T cell–related function. This work identified, as being of particular importance, a juxtamembrane domain region of BTN3A molecules identified as a possible dimerization interface and that is located close to the start of the B30.2 domain. | |||||
出版者 | ||||||
出版者 | The American Association of Immunologists, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1767 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/28461569 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.4049/jimmunol.1601910 | |||||
権利 | ||||||
権利情報 | © 2017 The American Association of Immunologists, Inc. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.jimmunol.org/content/198/11/4228 |