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Stochastic Spatially-Extended Simulations Predict the Effect of ER Distribution on Astrocytic Microdomain Ca²⁺ Activity
https://oist.repo.nii.ac.jp/records/2303
https://oist.repo.nii.ac.jp/records/2303282c4bdb-40d3-47c3-81d1-3c7c89d1c10a
名前 / ファイル | ライセンス | アクション |
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Denizot-2021-Stochastic Spatially-Extended Sim (1.3 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 会議発表論文 / Conference Paper(1) | |||||
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公開日 | 2021-09-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Stochastic Spatially-Extended Simulations Predict the Effect of ER Distribution on Astrocytic Microdomain Ca²⁺ Activity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | computational neuroscience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tripartite synapses | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | astrocytes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | calcium microdomain | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | reaction-diffusion simulations | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
資源タイプ | conference paper | |||||
著者 |
Denizot, Audrey
× Denizot, Audrey× Calì, Corrado× Berry, Hugues× De Schutter, Erik |
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書誌情報 |
en : NANOCOM '21: Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication p. 20, 発行日 2021-09-07 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Astrocytes are cells of the central nervous system that can regulate neuronal activity. Most astrocyte-neuron communication occurs at so-called tripartite synapses, where calcium signals are triggered in astrocytes by neuronal activity, resulting in the release of neuroactive molecules by the astrocyte. Most astrocytic Ca²⁺ signals occur in very thin astrocytic branchlets, containing low copy number of molecules, so that reactions are highly stochastic. As those sub-cellular compartments cannot be resolved by diffraction-limited microscopy techniques, stochastic reaction-diffusion computational approaches can give crucial insights on astrocyte activity. Here, we use our stochastic voxel-based model of IP3R-mediated Ca²⁺ signals to investigate the effect of the distance between the synapse and the closest astrocytic endoplasmic reticulum (ER) on neuronal activity-induced Ca²⁺ signals. Simulations are performed in three dimensional meshes characterized by various ER-synapse distances. Our results suggest that Ca2+ peak amplitude, duration and frequency decrease rapidly as ER-synapse distance increases. We propose that this effect mostly results from the increased cytosolic volume of branchlets that are characterized by larger ER-synapse distances. In particular, varying ER-synapse distance with constant cytosolic volume does not affect local Ca²⁺ activity. This study illustrates the insights that can be provided by three-dimensional stochastic reaction-diffusion simulations on the biophysical constraints that shape the spatio-temporal characteristics of astrocyte activity at the nanoscale. | |||||
出版者 | ||||||
出版者 | Association for Computing Machinery | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1145/3477206.3477456 | |||||
権利 | ||||||
権利情報 | © 2021 Copyright held by the owner/author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://dl.acm.org/doi/10.1145/3477206.3477456 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |