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CD4+T細胞におけるAP-1転写因子JunBの役割を解明
https://doi.org/10.15102/1394.00002111
https://doi.org/10.15102/1394.00002111c6777605-5508-420c-b5d9-b0f7e6482032
名前 / ファイル | ライセンス | アクション |
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Hsieh_FullText (11.7 MB)
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FinalExamAbstract-Hsieh (42.9 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2021-11-01 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | CD4+T細胞におけるAP-1転写因子JunBの役割を解明 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Deciphering the Role of AP-1 Transcription Factor JunB in CD4+ T Cells | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
ID登録 | ||||||||
ID登録 | 10.15102/1394.00002111 | |||||||
ID登録タイプ | JaLC | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 (英) |
Hsieh, Tsunghan
× Hsieh, Tsunghan
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抄録 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Differentiation of distinct CD4+ T effector cell subsets is a key event for adaptive immune responses. Upon recognition of antigens, naïve CD4+ T cells differentiate into functionally distinct CD4+ effector T cell subsets, which control different types of adaptive immunity. The differentiation of CD4+ T effector cells is regulated by the BATF-containing AP-1 heterodimers and their associating proteins IRF4, BATF and IRF4 are induced by T cell receptor (TCR) and co-stimulatory signals and regulate expression of genes required for a broad spectrum of biological functions across diverse CD4+ effector T cell subsets. These transcription factors have been shown to be essential for lineage specification, metabolic activity, and survival of various CD4+ effector T cell subsets, including T helper 1 (Th1), Th2, Th9, Th17, follicular T helper (Tfh) and effector regulator T (eTreg) cells. In contrast to IRF4 and BATF, the role of the major BATF-heterodimeric partner, JunB, in CD4+ T cell differentiation is still not fully understood. In this thesis, I demonstrate that JunB promotes the survival of TCR-stimulated CD4+ T cells under Th1-, Th2-, and Th17-polarizing conditions. Consistent with this, accumulation of antigen-primed JunB-deficient CD4+ T cells are dramatically impaired in mice immunized with complete Freund’s adjuvant (CFA), LPS, or papain. RNA-sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIPseq) analyses reveal that JunB directly regulates expression of various genes that are commonly induced in priming of naïve CD4+ T cells, including a pro-apoptotic gene Bcl2l11 (encoding Bim), and genes that are specifically induced in Th1, Th2, and Th17 cells. Furthermore, JunB colocalizes with BATF and IRF4 at genomic regions for more than 70% of JunB direct responsive genes. Taken together, JunB, in collaboration with BATF and IRF4, serves a critical function in differentiation of diverse CD4+ T cells by controlling common and lineage-specific gene expression. | |||||||
口頭試問日 | ||||||||
2021-09-14 | ||||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2021-10-31 | |||||||
学位名 | ||||||||
学位名 | Doctor of Philosophy | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第81号 | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 38005 | |||||||
学位授与機関名 | Okinawa Institute of Science and Technology Graduate University | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
権利 | ||||||||
権利情報 | © 2021 The Author |