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Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy
https://oist.repo.nii.ac.jp/records/2362
https://oist.repo.nii.ac.jp/records/236216c8800d-4f1e-43f2-aff1-f6b611474836
名前 / ファイル | ライセンス | アクション |
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fnbeh-15-785328_1 (495.9 kB)
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CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-29 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterizing Hippocampal Oscillatory Signatures Underlying Seizures in Temporal Lobe Epilepsy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | seizures | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hippocampus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biomarkers | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | temporal lobe epilepsy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | latent period | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pathological oscillations | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | high-frequency oscillations | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Mokhothu, Thato Mary
× Mokhothu, Thato Mary× Tanaka, Kazumasa |
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書誌情報 |
en : Frontiers in Behavioral Neuroscience 巻 15, p. 785328, 発行日 2021-11-25 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Temporal Lobe Epilepsy (TLE) is a neurological condition characterized by focal brain hyperexcitability, resulting in abnormal neuronal discharge and uncontrollable seizures. The hippocampus, with its inherently highly synchronized firing patterns and relatively high excitability, is prone to epileptic seizures, and it is usually the focus of TLE. Researchers have identified hippocampal high-frequency oscillations (HFOs) as a salient feature in people with TLE and animal models of this disease, arising before or at the onset of the epileptic event. To a certain extent, these pathological HFOs have served as a marker and a potential target for seizure attenuation using electrical or optogenetic interventions. However, many questions remain about whether we can reliably distinguish pathological from non-pathological HFOs and whether they can tell us about the development of the disease. While this would be an arduous task to perform in humans, animal models of TLE provide an excellent opportunity to study the characteristics of HFOs in predicting how epilepsy evolves. This minireview will (1) summarize what we know about the oscillatory disruption in TLE, (2) summarize knowledge about oscillatory changes in the latent period and their role in predicting seizures, and (3) propose future studies essential to uncovering potential treatments based on early detection of pathological HFOs. | |||||
出版者 | ||||||
出版者 | Frontiers Media | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1662-5153 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3389/fnbeh.2021.785328 | |||||
権利 | ||||||
権利情報 | © 2021 Mokhothu and Tanaka. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.785328/full | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |