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Mechanisms underlying microglial colonization of developing neural retina in zebrafish
https://oist.repo.nii.ac.jp/records/2419
https://oist.repo.nii.ac.jp/records/24191438bc95-56be-4ad8-b4eb-4146b3d66325
名前 / ファイル | ライセンス | アクション |
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elife-70550-v1 (13.6 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-12-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Mechanisms underlying microglial colonization of developing neural retina in zebrafish | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | blood vessel | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | developmental biology | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microglia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neurogenesis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neuroscience | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | retina | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | zebrafish | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Ranawat, Nishtha
× Ranawat, Nishtha× Masai, Ichiro |
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書誌情報 |
en : eLife 巻 10, p. e70550, 発行日 2021-12-07 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Microglia are brain-resident macrophages that function as the first line of defense in brain. Embryonic microglial precursors originate in peripheral mesoderm and migrate into the brain during development. However, the mechanism by which they colonize the brain is incompletely understood. The retina is one of the first brain regions to accommodate microglia. In zebrafish, embryonic microglial precursors use intraocular hyaloid blood vessels as a pathway to migrate into the optic cup via the choroid fissure. Once retinal progenitor cells exit the cell cycle, microglial precursors associated with hyaloid blood vessels start to infiltrate the retina preferentially through neurogenic regions, suggesting that colonization of retinal tissue depends upon the neurogenic state. Along with blood vessels and retinal neurogenesis, IL34 also participates in microglial precursor colonization of the retina. Altogether, CSF receptor signaling, blood vessels, and neuronal differentiation function as cues to create an essential path for microglial migration into developing retina. | |||||
出版者 | ||||||
出版者 | eLife Sciences Publications, Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2050-084X | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/34872632 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.7554/eLife.70550 | |||||
権利 | ||||||
権利情報 | © 2021 Ranawat and Masai. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://elifesciences.org/articles/70550 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |